概述

  • 产品名称
    Anti-Ensconsin抗体
    参阅全部 Ensconsin 一抗
  • 描述
    兔多克隆抗体to Ensconsin
  • 经测试应用
    适用于: IHC-P, IPmore details
    不适用于: WB
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Elephant
  • 免疫原

    Synthetic peptide corresponding to a region between residue 150 and 200 of human Ensconsin (NP_003971.1).

  • 阳性对照
    • Whole cell lysate from HeLa cells.

性能

应用

Our Abpromise guarantee covers the use of ab80416 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/500 - 1/2000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
IP Use at 2-5 µg/mg of lysate.
  • 应用说明
    Is unsuitable for WB.
  • 靶标

    • 功能
      Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments.
    • 组织特异性
      Expressed in the skin and cells of epithelial origin. Predominantly expressed in the suprabasal layers of the normal epidermis and relatively abundant in squamous cell carcinomas but barely detectable in basal cell carcinomas.
    • 序列相似性
      Belongs to the MAP7 family.
    • 翻译后修饰
      The association with microtubules is regulated by phosphorylation during the cell cycle. During interphase only phosphorylated on serine. Phosphorylated on threonine in mitosis.
    • 细胞定位
      Cytoplasm > perinuclear region. Basolateral cell membrane. Cytoplasm > cytoskeleton. Colocalized on microtubules. An intracellular redistribution is triggered during induction of keratinocyte terminal differentiation from microtubules with a perinuclear localization to cortical microtubules organized in spike-like bundles facing intercellular contacts.
    • Information by UniProt
    • 数据库链接
    • 别名
      • dJ325F22.2 (microtubule-associated protein 7 (EMAP115, E-MAP- 115)) antibody
      • E MAP 115 antibody
      • E-MAP-115 antibody
      • EMAP115 antibody
      • Ensconsin antibody
      • Epithelial microtubule associated protein of 115 kDa antibody
      • Epithelial microtubule-associated protein of 115 kDa antibody
      • MAP 7 antibody
      • MAP-7 antibody
      • Map7 antibody
      • MAP7_HUMAN antibody
      • Microtubule associated protein 7 antibody
      • Microtubule-associated protein 7 antibody
      see all

    图片

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human colon carcinoma tissue labelling Ensconsin with ab80416 at 1/1000 (1µg/ml). Detection: DAB.

    文献

    ab80416 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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