antigen sequence: LEVEPFESVH VYELMCRLLG IVPEANDGHL ATLLPMLHTE SALPPDGRPT LLPKGRSALP PSSRPLLVMG LLGTVILLSE, corresponding to amino acids 377-456 of Human ENPP7 (UniProt ID: Q6UWV6).
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol
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Immunogen affinity purified
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The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
||1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Converts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine. Does not appear to have nucleotide pyrophosphatase activity.
Detected in the colon (at protein level). Expressed in the duodenum, jejunum and liver and at low levels in the ileum. Expression was very low in the esophagus, stomach and colon.
Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
N-glycosylated; required for activity and transport to the plasma membrane.
Membrane. Localized at the surface of the microvillar membrane in small intestine enterocytes, and in endosome-like structures situated beneath the microvillar membrane, and in Golgi complex.
Information by UniProt
- ALK SMase antibody
- Alk-SMase antibody
- Alkaline sphingomyelin phosphodiesterase antibody
has not yet been referenced specifically in any publications.
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