Anti-Endothelin B Receptor抗体(ab117529)


  • 产品名称Anti-Endothelin B Receptor抗体
    参阅全部 Endothelin B Receptor 一抗
  • 描述
    兔多克隆抗体to Endothelin B Receptor
  • 经测试应用适用于: ICC, IHC-Fr, WB, IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
    预测可用于: Rabbit, Goat, Horse, Chicken, Cow, Dog, Pig, Rhesus monkey
  • 免疫原

    Synthetic peptide:


    conjugated to KLH, corresponding to C terminal amino acids 424-442 of Mouse Endothelin B Receptor.

  • 阳性对照
    • Mouse lung tissue; Mouse brain lysate; Endothelin B Receptor transfected cells


  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.02% Sodium azide
    Constituent: 99% Whole serum
  • 纯度Whole antiserum
  • 克隆多克隆
  • 同种型IgG
  • 研究领域


Our Abpromise guarantee covers the use of ab117529 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC 1/5000.
IHC-Fr 1/500 - 1/2000.
WB 1/5000. Predicted molecular weight: 50 kDa.
IHC-P 1/2000.
ICC/IF 1/5000.


  • 功能Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
  • 组织特异性Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells.
  • 疾病相关Defects in EDNRB are a cause of Waardenburg syndrome type 4A (WS4A) [MIM:277580]; also known as Waardenburg-Shah syndrome. WS4A is characterized by the association of Waardenburg features (depigmentation and deafness) and the absence of enteric ganglia in the distal part of the intestine (Hirschsprung disease).
    Defects in EDNRB are the cause of Hirschsprung disease type 2 (HSCR2) [MIM:600155]; also known as aganglionic megacolon (MGC). HSCR2 is a congenital disorder characterized by absence of enteric ganglia along a variable length of the intestine. It is the most common cause of congenital intestinal obstruction. Early symptoms range from complete acute neonatal obstruction, characterized by vomiting, abdominal distention and failure to pass stool, to chronic constipation in the older child.
    Defects in EDNRB are the cause of ABCD syndrome (ABCDS) [MIM:600501]. ABCD syndrome is an autosomal recessive syndrome characterized by albinism, black lock at temporal occipital region, bilateral deafness, aganglionosis of the large intestine and total absence of neurocytes and nerve fibers in the small intestine.
  • 序列相似性Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.
  • 翻译后修饰Palmitoylation of Cys-402 was confirmed by the palmitoylation of Cys-402 in a deletion mutant lacking both Cys-403 and Cys-405.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ABCDS antibody
    • Ednra antibody
    • EDNRB antibody
    • EDNRB_HUMAN antibody
    • Endothelin B receptor antibody
    • Endothelin B receptor precursor antibody
    • Endothelin receptor Non selective type antibody
    • Endothelin receptor non-selective type antibody
    • Endothelin receptor type B antibody
    • ET B antibody
    • ET-B antibody
    • ET-BR antibody
    • ETB antibody
    • ETBR antibody
    • ETRB antibody
    • Hirschsprung disease 2 antibody
    • HSCR antibody
    • HSCR2 antibody
    • OTTHUMP00000018534 antibody
    • OTTHUMP00000178736 antibody
    • WS4A antibody
    see all

Anti-Endothelin B Receptor antibody 图像

  • ab117529, at 1/5000 dilution, staining Endothelin B Receptor in HEK293 cells by Immunocytochemistry.
  • Anti-Endothelin B Receptor antibody (ab117529) at 1/5000 dilution + Mouse brain lysate

    Predicted band size : 50 kDa

Anti-Endothelin B Receptor antibody (ab117529)参考文献

ab117529 has not yet been referenced specifically in any publications.

Product Wall

Application Immunocytochemistry/ Immunofluorescence
Sample Human Cell (Blood)
Permeabilization No
Specification Blood
Blocking step Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 0.2% · Temperature: 37°C
Fixative life cell staining

Abcam user community

Verified customer

提交于 Oct 13 2015

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Blocking step Serum as blocking agent for 30 minute(s) · Concentration: 3% · Temperature: 20°C
Antigen retrieval step Heat mediated - Buffer/Enzyme Used: Citrat-Buffer pH 6,0
Sample Mouse Tissue sections (lung)
Specification lung
Permeabilization No
Fixative Formaldehyde

Abcam user community

Verified customer

提交于 Jun 05 2013

I am sorry for the delay in getting back to you.
I now have confirmation that the antigen retrieval method we have used with the anti-Endothelin B Receptor antibody (ab117529) to obtain the image presented on the datasheet was citric acid buffer (...

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Thank you for contacting us and your interest in our products.
Our Endothelin Receptor B Polyclonal Antibody - product ab117529 is provided as undiluted antisera. This contains many other proteins other than the specific antibodies and quantificat...

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Es freut mich zu hören, dass Sie unser Angebot unseren Antikörper ab84182 Anti-Endothelin B Receptor antibody - C-terminal in IHC-Fr zu testen, annehmen möchten. Wie am Telefon besprochen, können Sie den Gutscheincode zum Kauf eines weiteren Antikörper...

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Vielen Dank für Ihren Anruf und für Ihr Interesse an unseren Produkten.

Unseres Wissens nach wurde ab117529 Anti-Endothelin B Receptor antibody bisher noch nicht inIHC-Fr getestet. Falls Sie dies selbst testen möchten, kann ic...

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