Anti-Endothelin A Receptor抗体(ab30536)

概述

  • 产品名称Anti-Endothelin A Receptor抗体
    参阅全部 Endothelin A Receptor 一抗
  • 描述
    羊多克隆抗体to Endothelin A Receptor
  • 经测试应用适用于: WB, ELISA, IP, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Rat, Sheep, Human
    预测可用于: Cow
  • 免疫原

    Synthetic peptide:

    QEQNHNTERSSHK

    conjugated to KLH, corresponding to C terminal amino acids 410-422 of Rat Endothelin A Receptor

  • 阳性对照
    • Endothelin A receptor transfected COS cells.

性能

应用

Our Abpromise guarantee covers the use of ab30536 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration.
ELISA Use at an assay dependent concentration.
IP Use at an assay dependent concentration.
IHC-P Use at an assay dependent concentration.

靶标

  • 功能Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
  • 组织特异性Isoform 1, isoform 3 and isoform 4 are expressed in a variety of tissues, with highest levels in the aorta and cerebellum, followed by lung, atrium and cerebral cortex, lower levels in the placenta, kidney, adrenal gland, duodenum, colon, ventricle and liver but no expression in umbilical vein endothelial cells. Within the placenta, isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in the villi and stem villi vessels.
  • 序列相似性Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Ednra antibody
    • EDNRA_HUMAN antibody
    • Endothelin 1 receptor precursor antibody
    • Endothelin 1 specific receptor antibody
    • Endothelin A receptor antibody
    • Endothelin ET A receptor antibody
    • Endothelin receptor ET1 specific type antibody
    • Endothelin receptor subtype A antibody
    • Endothelin receptor type A antibody
    • Endothelin-1 receptor antibody
    • ET A antibody
    • ET-A antibody
    • ETA antibody
    • ETA R antibody
    • ETA-R antibody
    • ETAR antibody
    • ETRA antibody
    • hET AR antibody
    • hET-AR antibody
    see all

Anti-Endothelin A Receptor antibody (ab30536)参考文献

This product has been referenced in:
  • Riemekasten G  et al. Involvement of functional autoantibodies against vascular receptors in systemic sclerosis. Ann Rheum Dis 70:530-6 (2011). WB ; Human . Read more (PubMed: 21081526) »

See 1 Publication for this product

Product Wall

Thank you for contacting us. At this time we do not offer the blocking peptide forthese products. However the immunogen sequences of both products are available on our website. You may be able to have custom peptide created from these for use as a bloc...

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Thank you for your enquiry. Unfortunately, we do not have the IHC image available. However, the we do have the protocols as below. IHC-Paraffin (Tissue section: lung and intestine) Fixed paraffin-embedded sections (4-6 mm) are deparaffinized...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"