Anti-Endothelin 3抗体(Biotin) (ab48253)

概述

  • 产品名称
    Anti-Endothelin 3抗体(Biotin)
    参阅全部 Endothelin 3 一抗
  • 描述
    兔多克隆抗体to Endothelin 3 (Biotin)
  • 偶联物
    Biotin
  • 经测试应用
    适用于: IP, RIA, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Horse, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide:

    CTCFTYKDKECVYYCHLDIIW

    conjugated to KLH, corresponding to amino acids 97-117 of Human Endothelin 3

性能

应用

Our Abpromise guarantee covers the use of ab48253 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at an assay dependent dilution.
RIA Use at an assay dependent dilution.
ELISA Use at an assay dependent dilution.

靶标

  • 功能
    Endothelins are endothelium-derived vasoconstrictor peptides.
  • 组织特异性
    Expressed in trophoblasts and placental stem villi vessels, but not in cultured placental smooth muscle cells.
  • 疾病相关
    Defects in EDN3 are the cause of Hirschsprung disease type 4 (HSCR4) [MIM:613712]; also known as aganglionic megacolon (MGC). A genetic disorder of neural crest development characterized by the absence of intramural ganglion cells in the hindgut; often resulting in intestinal obstruction.
    Defects in EDN3 are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia.
    Defects in EDN3 are a cause of Waardenburg syndrome type 4 (WS4B) [MIM:613265]; also known as Waardenburg-Shah syndrome. WS4B is characterized by the association of Waardenburg features (depigmentation and deafness) and the absence of enteric ganglia in the distal part of the intestine (Hirschsprung disease).
  • 序列相似性
    Belongs to the endothelin/sarafotoxin family.
  • 细胞定位
    Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • EDN3 antibody
    • EDN3_HUMAN antibody
    • Endothelin-3 antibody
    • ET 3 antibody
    • ET-3 antibody
    • PPET3 antibody
    • Preproendothelin 3 antibody
    • Preproendothelin-3 antibody
    see all

文献

ab48253 has not yet been referenced specifically in any publications.

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