Anti-Endothelin 3抗体(ab54952)

概述

  • 产品名称Anti-Endothelin 3抗体
    参阅全部 Endothelin 3 一抗
  • 描述
    小鼠单克隆抗体to Endothelin 3
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length protein, corresponding to amino acids 1-239 of Human Endothelin 3

性能

应用

Our Abpromise guarantee covers the use of ab54952 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Endothelins are endothelium-derived vasoconstrictor peptides.
    • 组织特异性Expressed in trophoblasts and placental stem villi vessels, but not in cultured placental smooth muscle cells.
    • 疾病相关Defects in EDN3 are the cause of Hirschsprung disease type 4 (HSCR4) [MIM:613712]; also known as aganglionic megacolon (MGC). A genetic disorder of neural crest development characterized by the absence of intramural ganglion cells in the hindgut; often resulting in intestinal obstruction.
      Defects in EDN3 are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia.
      Defects in EDN3 are a cause of Waardenburg syndrome type 4 (WS4B) [MIM:613265]; also known as Waardenburg-Shah syndrome. WS4B is characterized by the association of Waardenburg features (depigmentation and deafness) and the absence of enteric ganglia in the distal part of the intestine (Hirschsprung disease).
    • 序列相似性Belongs to the endothelin/sarafotoxin family.
    • 细胞定位Secreted.
    • Information by UniProt
    • 数据库链接
    • 别名
      • EDN3 antibody
      • EDN3_HUMAN antibody
      • Endothelin-3 antibody
      • ET 3 antibody
      • ET-3 antibody
      • PPET3 antibody
      • Preproendothelin 3 antibody
      • Preproendothelin-3 antibody
      see all

    Anti-Endothelin 3 antibody 图像



    • Predicted band size : 25 kDa
      Endothelin 3 antibody (ab54952) at 1ug/lane + LNCaP cell lysate at 25ug/lane.

    Anti-Endothelin 3 antibody (ab54952)参考文献

    ab54952 has not yet been referenced specifically in any publications.

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