Anti-Emerin抗体[MANEM1(5D10)] (ab125932)


  • 产品名称Anti-Emerin抗体[MANEM1(5D10)]
    参阅全部 Emerin 一抗
  • 描述
    小鼠单克隆抗体[MANEM1(5D10)] to Emerin
  • 经测试应用适用于: ICC/IF, WBmore details
  • 种属反应性
    与反应: Rabbit, Human
    不与反应: Mouse
  • 免疫原

    Recombinant fragment of Emerin amino acids 1-188(Human)

  • 阳性对照
    • Human fibroblast cells and cell extracts.


  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 0.1% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆单克隆
  • 克隆编号MANEM1(5D10)
  • 骨髓瘤Sp2/0
  • 同种型IgG1
  • 研究领域


Our Abpromise guarantee covers the use of ab125932 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF 1/4 - 1/10.
WB 1/400 - 1/800. Predicted molecular weight: 29 kDa.


  • 功能Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C.
  • 组织特异性Skeletal muscle, heart, colon, testis, ovary and pancreas.
  • 疾病相关Defects in EMD are the cause of Emery-Dreifuss muscular dystrophy type 1 (EDMD1) [MIM:310300]. A degenerative myopathy characterized by weakness and atrophy of muscle without involvement of the nervous system, early contractures of the elbows Achilles tendons and spine, and cardiomyopathy associated with cardiac conduction defects.
  • 序列相似性Contains 1 LEM domain.
  • 翻译后修饰Found in four different phosphorylated forms, three of which appear to be associated with the cell cycle.
  • 细胞定位Nucleus inner membrane. Nucleus outer membrane. Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non-farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • EDMD antibody
    • Emd antibody
    • EMD_HUMAN antibody
    • Emerin antibody
    • Emery Dreifuss muscular dystrophy antibody
    • STA antibody
    see all

Anti-Emerin antibody [MANEM1(5D10)] 图像

  • Anti-Emerin antibody [MANEM1(5D10)] (ab125932) at 1/400 dilution + Normal Human fibroblast extracts

    Predicted band size : 29 kDa
  • ab125932 at 1/4 dilution staining Emerin in Human fibroblasts by Immunofluorescence. DAPI counterstaining.

Anti-Emerin antibody [MANEM1(5D10)] (ab125932)参考文献

ab125932 has not yet been referenced specifically in any publications.

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