概述

  • 产品名称Anti-ELMO2抗体
    参阅全部 ELMO2 一抗
  • 描述
    山羊多克隆抗体to ELMO2
  • 特异性This antibody is expected to recognise both human isoforms.
  • 经测试应用适用于: IHC-P, ICC/IF, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Dog, Pig
  • 免疫原

    Synthetic peptide: PKEPSSYDFVYHYG, corresponding to C terminal amino acids 707-720 of Human ELMO2.

性能

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应用

Our Abpromise guarantee covers the use of ab2240 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 3 - 6 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use at an assay dependent concentration. PubMed: 24446484
WB Use a concentration of 1 - 3 µg/ml. Can be blocked with Human ELMO2 peptide (ab22879).

靶标

  • 功能Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
  • 组织特异性Widely expressed, with a higher expression in skeletal muscle, kidney and placenta.
  • 序列相似性Contains 1 ELMO domain.
    Contains 1 PH domain.
  • 细胞定位Cytoplasm. Cytoplasm > cytosol. Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CED 12 antibody
    • Ced 12 homolog 2 antibody
    • CED 12 homolog A antibody
    • CED 12A antibody
    • CED-12 antibody
    • ced-12 homolog 2 antibody
    • CED12 antibody
    • CED12 homolog A antibody
    • CED12, C. elegans, homolog of, 2 antibody
    • CED12A antibody
    • ELMO 2 antibody
    • ELMO-2 antibody
    • ELMO2 antibody
    • ELMO2_HUMAN antibody
    • Engulfment and cell motility 2 (ced 12 homolog, C. elegans) antibody
    • Engulfment and cell motility 2 antibody
    • Engulfment and cell motility gene 2 antibody
    • Engulfment and cell motility protein 2 antibody
    • FLJ11656 antibody
    • hCED 12A antibody
    • hCED-12A antibody
    • hCED12A antibody
    • KIAA1834 antibody
    • OTTHUMP00000031762 antibody
    • PH domain protein CED12A antibody
    • Protein ced 12 homolog A antibody
    • Protein ced-12 homolog A antibody
    see all

Anti-ELMO2 antibody 图像

  • Ab2240 staining (2µg/ml) of Human Brain lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 12 hour. Detected by western blot using chemiluminescence.
  • ab2240 at 3.8 µg/ml staining ELMO2 in Human prostate tissue by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).

Anti-ELMO2 antibody (ab2240)参考文献

This product has been referenced in:
  • Toret CP  et al. A genome-wide screen identifies conserved protein hubs required for cadherin-mediated cell-cell adhesion. J Cell Biol 204:265-79 (2014). ICC/IF, WB ; Drosophila melanogaster . Read more (PubMed: 24446484) »
  • Toret CP  et al. An Elmo-Dock complex locally controls Rho GTPases and actin remodeling during cadherin-mediated adhesion. J Cell Biol 207:577-87 (2014). Read more (PubMed: 25452388) »

See all 5 Publications for this product

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