概述

  • 产品名称Anti-Elf4/MEF抗体
    参阅全部 Elf4/MEF 一抗
  • 描述
    兔多克隆抗体to Elf4/MEF
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    A KLH conjugated synthetic peptide selected from the Center region of human ELF4.

  • 阳性对照
    • 293 cell lysate

性能

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应用

Our Abpromise guarantee covers the use of ab82396 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/50 - 1/100. Detects a band of approximately 71 kDa (predicted molecular weight: 71 kDa).
ELISA 1/1000.

靶标

  • 功能Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote celular transformation through inhibition of the p16 pathway.
  • 组织特异性Abundantly expressed in the placenta and in a variety of myeloid leukemia cell lines. Moderate levels of expression in heart, lung, spleen, thymus, peripheral blood lymphocytes, ovary and colon. Lower levels of expression in Jurkat T-cells and other T-cell lines and no expression in brain.
  • 疾病相关A chromosomal aberration involving ELF4 is a cause of acute myeloid leukemia (AML). Translocation t(X;21)(q25-26;q22) with ERG.
  • 序列相似性Belongs to the ETS family.
    Contains 1 ETS DNA-binding domain.
  • 细胞定位Nucleus > PML body. Accumulation into PML nuclear bodies is mediated by PML.
  • Information by UniProt
  • 数据库链接
  • 别名
    • E74-like factor 4 antibody
    • ELF4 antibody
    • ELF4_HUMAN antibody
    • ELFR antibody
    • ETS-related transcription factor Elf-4 antibody
    • ETS-related transcription factor Elf4 antibody
    • MEF antibody
    • Myeloid Elf-1-like factor antibody
    • Myeloid Elf1-like factor antibody
    see all

Anti-Elf4/MEF antibody 图像

  • Anti-Elf4/MEF antibody (ab82396) at 1/50 dilution + 293 cell line lysates at 12.5 µg

    Predicted band size : 71 kDa
    Observed band size : 71 kDa

Anti-Elf4/MEF antibody (ab82396)参考文献

ab82396 has not yet been referenced specifically in any publications.

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