概述

  • 产品名称Anti-ELAC2抗体
    参阅全部 ELAC2 一抗
  • 描述
    兔多克隆抗体to ELAC2
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthesized peptide derived from the internal region of Human ELAC2

  • 阳性对照
    • Human brain tissue

性能

应用

Our Abpromise guarantee covers the use of ab110953 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
  • 组织特异性Widely expressed. Highly expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, testis and ovary. Weakly expressed in brain, lung, spleen, thymus, prostate, small intestine, colon and leukocytes.
  • 疾病相关Defects in ELAC2 may be a cause of susceptibility to prostate cancer (PC) [MIM:176807]. It is a malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
  • 序列相似性Belongs to the RNase Z family.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • COXPD17 antibody
    • elaC homolog 2 (E. coli) antibody
    • ElaC homolog protein 2 antibody
    • elaC ribonuclease Z 2 antibody
    • elaC, E. coli, homolog of, 2 antibody
    • ELAC2 antibody
    • ELC2 antibody
    • FLJ10530 antibody
    • FLJ36693 antibody
    • FLJ42848 antibody
    • Heredity prostate cancer protein 2 antibody
    • HPC2 antibody
    • putative prostate cancer susceptibility protein HPC2/ELAC2 antibody
    • Ribonuclease Z 2 antibody
    • Ribonuclease Z, long form antibody
    • Ribonuclease Z2 antibody
    • RNase Z 2 antibody
    • RNase Z2 antibody
    • RNase ZL antibody
    • RNZ2_HUMAN antibody
    • tRNA 3 endonuclease 2 antibody
    • tRNase Z (long form) antibody
    • tRNase Z 2 antibody
    • tRNase Z2 antibody
    • Zinc phosphodiesterase ELAC protein 2 antibody
    see all

Anti-ELAC2 antibody 图像

  • Immunohistochemistry analysis of paraffin-embedded Human brain tissue, using a/50 ab111953. The picture on the right is treated with the synthesized peptide

Anti-ELAC2 antibody (ab110953)参考文献

ab110953 has not yet been referenced specifically in any publications.

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