概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 序列ATAETALPSISTLT-C

相关产品

技术指标

Our Abpromise guarantee covers the use of ab45462 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-EKLF / KLF1 antibody - ChIP Grade (ab2483)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C.

常规信息

  • 别名
    • CDAN4
    • EKLF
    • EKLF PEN
    • Erythroid krueppel like transcription factor (EKLF) (Erythroid transcription factor)
    • Erythroid krueppel-like transcription factor
    • Erythroid Kruppel like factor
    • Erythroid specific transcription factor EKLF
    • HBFQTL6
    • Human erythroid-specific transcription factor EKLF mRNA complete cds
    • INLU
    • Klf1
    • KLF1_HUMAN
    • Krueppel-like factor 1
    • Kruppel like factor 1 (erythroid)
    see all
  • 功能Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.
  • 组织特异性Expression restricted to adult bone marrow and fetal liver. Not expressed in myeloid nor lymphoid cell lines.
  • 疾病相关Defects in KLF1 are the cause of congenital dyserythropoietic anemia type 4 (CDA4) [MIM:613673]. It is a blood disorder characterized by ineffective erythropoiesis and hemolysis resulting in anemia. Circulating erythroblasts and erythroblasts in the bone marrow show various morphologic abnormalities. Affected individuals with CDA4 also have increased levels of fetal hemoglobin.
  • 序列相似性Belongs to the krueppel C2H2-type zinc-finger protein family.
    Contains 3 C2H2-type zinc fingers.
  • 翻译后修饰Acetylated; can be acetylated on both Lys-274 and Lys-288. Acetylation on Lys-274 (by CBP) appears to be the major site affecting EKLF transactivation activity.
    Sumoylated; sumoylation, promoted by PIAS1, leads to repression of megakaryocyte differentiation. Also promotes the interaction with the CDH4 subunit of the NuRD repression complex.
    Phosphorylated primarily on serine residues in the transactivation domain. Phosphorylation on Thr-23 is critical for the transactivation activity.
  • 细胞定位Nucleus. Colocalizes with SUMO1 in nuclear speckles.
  • Information by UniProt

EKLF / KLF1 peptide (ab45462)参考文献

ab45462 has not yet been referenced specifically in any publications.

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