概述

  • 产品名称Anti-eIF5A2抗体
    参阅全部 eIF5A2 一抗
  • 描述
    兔多克隆抗体to eIF5A2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide containing a sequence corresponding to a region within amino acids 89-153 of Human eIF5A2 (NP_065123).

  • 阳性对照
    • 293T, A431, H1299, HeLaS3, HepG2, Molt-4 and Raji whole cell lysates

性能

应用

Our Abpromise guarantee covers the use of ab97314 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 17 kDa.

靶标

  • 功能mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation.
  • 组织特异性Expressed in ovarian and colorectal cancer cell lines (at protein level). Highly expressed in testis. Overexpressed in some cancer cells.
  • 序列相似性Belongs to the eIF-5A family.
  • 翻译后修饰eIF-5A seems to be the only eukaryotic protein to have an hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).
  • 细胞定位Cytoplasm. Nucleus. Endoplasmic reticulum membrane. Nucleus > nuclear pore complex. Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 9630038B20 antibody
    • eIF 5A 2 antibody
    • eIF 5A2 antibody
    • eIF-4D antibody
    • eIF-5A-2 antibody
    • eIF-5A2 antibody
    • EIF5A 2 antibody
    • EIF5A2 antibody
    • eIF5AII antibody
    • Eukaryotic initiation factor 5A isoform 2 antibody
    • Eukaryotic translation initiation factor 5A-2 antibody
    • Eukaryotic translation initiation factor 5A2 antibody
    • IF5A2_HUMAN antibody
    see all

Anti-eIF5A2 antibody 图像

  • All lanes : Anti-eIF5A2 antibody (ab97314) at 1/1000 dilution

    Lane 1 : 293T whole cell lysate
    Lane 2 : A431 whole cell lysate
    Lane 3 : H1299 whole cell lysate
    Lane 4 : HeLaS3 whole cell lysate
    Lane 5 : HepG2 whole cell lysate
    Lane 6 : Molt-4 whole cell lysate
    Lane 7 : Raji whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 17 kDa

Anti-eIF5A2 antibody (ab97314)参考文献

ab97314 has not yet been referenced specifically in any publications.

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