概述

  • 产品名称Anti-eIF5A抗体
    参阅全部 eIF5A 一抗
  • 描述
    山羊多克隆抗体to eIF5A
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide to the N terminal region of Human eIF5A.
    (NP_001137233.1, NP_001961.1 and NP_001137234.1)

  • 阳性对照
    • Human Vessel, Spleen, Tonsil tissues and MOLT4 lysate

性能

应用

Our Abpromise guarantee covers the use of ab119115 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 17 kDa.
IHC-P Use a concentration of 3.75 µg/ml.

靶标

  • 功能mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.
  • 组织特异性Expressed in umbilical vein endothelial cells and several cancer cell lines (at protein level).
  • 序列相似性Belongs to the eIF-5A family.
  • 翻译后修饰eIF-5A seems to be the only eukaryotic protein to have an hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).
  • 细胞定位Cytoplasm. Nucleus. Endoplasmic reticulum membrane. Nucleus > nuclear pore complex. Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions.
  • Information by UniProt
  • 数据库链接
  • 别名
    • eIF 4D antibody
    • eIF 5A 1 antibody
    • EIF 5A antibody
    • eIF 5A1 antibody
    • eIF-4D antibody
    • eIF-5A antibody
    • eIF-5A-1 antibody
    • eIF-5A1 antibody
    • eIF4D antibody
    • eif5a antibody
    • EIF5A1 antibody
    • eIF5AI antibody
    • Eukaryotic initiation factor 5A antibody
    • Eukaryotic initiation factor 5A isoform 1 antibody
    • Eukaryotic translation initiation factor 5A 1 antibody
    • Eukaryotic translation initiation factor 5A antibody
    • Eukaryotic translation initiation factor 5A-1 antibody
    • IF5A1_HUMAN antibody
    • MGC104255 antibody
    • MGC99547 antibody
    • Rev binding factor antibody
    • Rev-binding factor antibody
    • uORF A antibody
    • uORF antibody
    see all

Anti-eIF5A antibody 图像

  • Anti-eIF5A antibody (ab119115) at 0.1 µg/ml (incubated for 1 hour ) + MOLT4 lysate in RIPA buffer at 35 µg
    Developed using the ECL technique

    Predicted band size : 17 kDa
  • Immunohistochemistry on Formalin-Fixed, Paraffin-Embedded Human Vessel tissue using ab119115 at 3.75 µg/ml.
  • Immunohistochemistry on Formalin-Fixed, Paraffin-Embedded Human Spleen tissue using ab119115 at 3.75 µg/ml.
  • Immunohistochemistry on Formalin-Fixed, Paraffin-Embedded Human Tonsil tissue using ab119115 at 3.75 µg/ml.

Anti-eIF5A antibody (ab119115)参考文献

ab119115 has not yet been referenced specifically in any publications.

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