概述

  • 产品名称Anti-eIF4H抗体
    参阅全部 eIF4H 一抗
  • 描述
    兔多克隆抗体to eIF4H
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Chimpanzee, Rhesus monkey, Gorilla, Chinese Hamster, Orangutan
  • 免疫原

    Synthetic peptide, corresponding to a region within amino acids 198-248 of Human eIF4H (NP_071496.1).

  • 阳性对照
    • Human Colon Carcinoma, Prostate Carcinoma and Testicular Seminoma tissues

性能

应用

Our Abpromise guarantee covers the use of ab114850 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining

靶标

  • 功能Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.
  • 组织特异性The short isoform is the predominant isoform and is expressed alone in liver and skeletal muscle. Both isoforms are expressed in fibroblast, spleen, testis and bone marrow. Levels are high in lung and pancreas and low in heart, frontal cortex and kidney.
  • 疾病相关Note=EIF4H is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of EIF4H may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
  • 序列相似性Contains 1 RRM (RNA recognition motif) domain.
  • 细胞定位Cytoplasm > perinuclear region.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AU018978 antibody
    • D5Ertd355e antibody
    • E430026L18Rik antibody
    • Ef4h antibody
    • eIF 4H antibody
    • eIF-4H antibody
    • EIF4H antibody
    • Eukaryotic translation initiation factor 4H antibody
    • IF4H_HUMAN antibody
    • KIAA0038 antibody
    • WBSCR1 antibody
    • Williams Beuren syndrome chromosomal region 1 protein homolog antibody
    • Williams Beuren syndrome chromosome region 1 antibody
    • Williams-Beuren syndrome chromosomal region 1 protein antibody
    • Williams-Beuren syndrome chromosome region 1 antibody
    • WSCR1 antibody
    see all

Anti-eIF4H antibody 图像

  • ab114850, at 1/250 dilution, staining eIF4H in formalin-fixed, paraffin-embedded Human prostate carcinoma tissue by Immunohistochemistry with DAB staining.

Anti-eIF4H antibody (ab114850)参考文献

ab114850 has not yet been referenced specifically in any publications.

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