概述

  • 产品名称Anti-eIF4G1抗体
    参阅全部 eIF4G1 一抗
  • 描述
    小鼠单克隆抗体to eIF4G1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: DVAVLKARAK LLQKYLCDEQ KELQALYALQ ALVVTLEQPP NLLRMFFDAL YDEDVVKEDA FYSWESSKDP AEQQGKGVAL KSVTAFFKWL REAEEESDHN , corresponding to amino acids 1500-1600 of Human eIF4G1

性能

应用

Our Abpromise guarantee covers the use of ab54970 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.
    • 疾病相关Defects in EIF4G1 are the cause of Parkinson disease type 18 (PARK18) [MIM:614251]. An autosomal dominant, late-onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.
    • 序列相似性Belongs to the eIF4G family.
      Contains 1 MI domain.
      Contains 1 MIF4G domain.
      Contains 1 W2 domain.
    • 翻译后修饰Phosphorylated at multiple sites in vivo. Phosphorylation at Ser-1185 by PRKCA induces binding to MKNK1.
      Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription.
    • Information by UniProt
    • 数据库链接
    • 别名
      • DKFZp686A1451 antibody
      • eIF 4 gamma 1 antibody
      • eIF 4G 1 antibody
      • eIF 4G1 antibody
      • eIF-4-gamma 1 antibody
      • eIF-4G 1 antibody
      • eIF-4G1 antibody
      • EIF4 gamma antibody
      • EIF4F antibody
      • EIF4G antibody
      • EIF4G1 antibody
      • EIF4GI antibody
      • Eukaryotic translation initiation factor 4 gamma 1 antibody
      • IF4G1_HUMAN antibody
      • p220 antibody
      see all

    Anti-eIF4G1 antibody 图像



    • Predicted band size : 176 kDa
      eIF4G1 antibody (ab54970) at 1ug/lane + HepG2 cell lysate at 25ug/lane.

    Anti-eIF4G1 antibody (ab54970)参考文献

    This product has been referenced in:
    • Gumireddy K  et al. Identification of a long non-coding RNA-associated RNP complex regulating metastasis at the translational step. EMBO J 32:2672-84 (2013). Read more (PubMed: 23974796) »

    See 1 Publication for this product

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