Anti-eIF4EBP1 (phospho T70)抗体(ab111421)

概述

  • 产品名称Anti-eIF4EBP1 (phospho T70)抗体
    参阅全部 eIF4EBP1 一抗
  • 描述
    兔多克隆抗体to eIF4EBP1 (phospho T70)
  • 特异性Detects endogenous levels of eIF4EBP1 only when phosphorylated at threonine70.
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide derived from human eIF4EBP1 (Q13541) around the phosphorylation site of Thr70 (T-K-TP-P-P).

  • 阳性对照
    • Human colon carcinoma tissue.

性能

应用

Our Abpromise guarantee covers the use of ab111421 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
  • 序列相似性Belongs to the eIF4E-binding protein family.
  • 翻译后修饰Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylation at Thr-37, Thr-46, Ser-65 and Thr-70 is regulated by mTORC1. Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 4E-BP1 antibody
    • 4EBP1 antibody
    • 4EBP1_HUMAN antibody
    • BP 1 antibody
    • eIF4E binding protein 1 antibody
    • eIF4E-binding protein 1 antibody
    • Eif4ebp1 antibody
    • Eukaryotic translation initiation factor 4E-binding protein 1 antibody
    • PHAS-I antibody
    • PHASI antibody
    • Phosphorylated heat- and acid-stable protein regulated by insulin 1 antibody
    see all

Anti-eIF4EBP1 (phospho T70) antibody 图像

  • Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using eIF4EBP1 (Phospho-Thr70) Antibody (ab111421). The picture on the right is treated with the synthesized phospho peptide.

Anti-eIF4EBP1 (phospho T70) antibody (ab111421)参考文献

ab111421 has not yet been referenced specifically in any publications.

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