概述

  • 产品名称Anti-eIF4EBP1抗体
    参阅全部 eIF4EBP1 一抗
  • 描述
    兔多克隆抗体to eIF4EBP1
  • 经测试应用适用于: ICC/IF, WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    14 amino acid synthetic peptide from near the C terminus of eIF4EBP1 (Human).

  • 阳性对照
    • 3T3 cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab25872 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use a concentration of 2 µg/ml.
WB Use a concentration of 2.5 - 5 µg/ml. Detects a band of approximately 20 kDa (predicted molecular weight: 13 kDa).

靶标

  • 功能Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
  • 序列相似性Belongs to the eIF4E-binding protein family.
  • 翻译后修饰Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylation at Thr-37, Thr-46, Ser-65 and Thr-70 is regulated by mTORC1. Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 4E-BP1 antibody
    • 4EBP1 antibody
    • 4EBP1_HUMAN antibody
    • BP 1 antibody
    • eIF4E binding protein 1 antibody
    • eIF4E-binding protein 1 antibody
    • Eif4ebp1 antibody
    • Eukaryotic translation initiation factor 4E-binding protein 1 antibody
    • PHAS-I antibody
    • PHASI antibody
    • Phosphorylated heat- and acid-stable protein regulated by insulin 1 antibody
    see all

Anti-eIF4EBP1 antibody 图像

  • Lane 1 : Anti-eIF4EBP1 antibody (ab25872) at 2.5 µg/ml
    Lane 2 : Anti-eIF4EBP1 antibody (ab25872) at 5 µg/ml
    Lane 3 : Anti-eIF4EBP1 antibody (ab25872) at 10 µg/ml

    Lane 1 : Human brain cell lysate
    Lane 2 : Human brain cell lysate
    Lane 3 : Human brain cell lysate


    Predicted band size : 13 kDa
  • ab25872 at 2µg/ml staining elf4EBP1 in 3T3 cells by ICC/IF

Anti-eIF4EBP1 antibody (ab25872)参考文献

ab25872 has not yet been referenced specifically in any publications.

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