功能Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling.
序列相似性Belongs to the eIF-3 subunit F family. Contains 1 MPN (JAB/Mov34) domain.
Immunohistochemistry analysis of EIF3F in paraffin-embedded
human brain tissue using ab74568, at 1/50-1/100 dilution, in the presence (right panel) or absence (left panel) of immunising peptide.
Anti-EIF3F antibody (ab74568)参考文献
This product has been referenced in:
Villa N et al. Human eukaryotic initiation factor 4G (eIF4G) protein binds to eIF3c, -d, and -e to promote mRNA recruitment to the ribosome. J Biol Chem288:32932-40 (2013).
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