Anti-eIF3A抗体(ab105113)
Key features and details
- Rabbit polyclonal to eIF3A
- Suitable for: IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
概述
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产品名称
Anti-eIF3A抗体
参阅全部 eIF3A 一抗 -
描述
兔多克隆抗体to eIF3A -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Mouse, Human
预测可用于: Rat, Rabbit, Guinea pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan -
免疫原
Synthetic peptide, corresponding to a region within amino acids 860-910 of Human eIF3A (NP_003741.1; GeneID 8661).
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阳性对照
- Human Controls: Anaplastic Thyroid Carcinoma, Breast Carcinoma, Colon Carcinoma Mouse Controls: Colon Carcinoma CT26, Renal Cell Carcinoma
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 6.8
Preservative: 0.09% Sodium azide
Constituents: 0.1% BSA, Tris buffered saline -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab105113于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P |
1/100 - 1/500. Epitope exposure with tris-EDTA pH9.0 buffer will enhance staining.
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说明 |
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IHC-P
1/100 - 1/500. Epitope exposure with tris-EDTA pH9.0 buffer will enhance staining. |
靶标
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功能
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634). In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426). -
序列相似性
Belongs to the eIF-3 subunit A family.
Contains 1 PCI domain. -
翻译后修饰
Phosphorylated. Phosphorylation is enhanced upon serum stimulation. -
细胞定位
Cytoplasm. - Information by UniProt
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数据库链接
- Entrez Gene: 466216 Chimpanzee
- Entrez Gene: 8661 Human
- Entrez Gene: 13669 Mouse
- Entrez Gene: 292148 Rat
- Omim: 602039 Human
- SwissProt: Q14152 Human
- SwissProt: P23116 Mouse
- SwissProt: G1SMZ5 Rabbit
see all -
别名
- centrosomin homolog antibody
- cytoplasmic protein p167 antibody
- eIF 3 theta antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab105113 尚未被引用在任何文献中。