概述

  • 产品名称
  • 描述
    兔多克隆抗体to EI24
  • 特异性
    At least two isoforms of EI24 are known to exist; ab117463 will only detect the larger isoform.
  • 经测试应用
    适用于: ICC, WBmore details
  • 种属反应性
    与反应: Rat
    预测可用于: Mouse, Human
  • 免疫原

    Synthetic peptide corresponding to 19 amino acids near the C terminal of Human EI24 (NP_004870).

  • 阳性对照
    • Rat liver tissue lysate.
  • 常规说明
    Avoid repeated freeze thaw cycles and exposure to prolonged high temperatures.

性能

应用

Our Abpromise guarantee covers the use of ab117463 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC Use a concentration of 5 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 39 kDa.

靶标

  • 功能
    Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy.
  • 疾病相关
    Note=EI24 is on a chromosomal region frequently deleted in solid tumors, and it is thought to play a role in breast and cervical cancer. Particularly, expression analysis of EI24 in cancerous tissues shows that EI24 loss is associated with tumor invasiveness.
  • 序列相似性
    Belongs to the EI24 family.
  • 细胞定位
    Nucleus membrane. Cytoplasm. Endoplasmic reticulum membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Ectopic P granules autophagy protein 4 homolog antibody
    • Ei24 antibody
    • EI24_HUMAN antibody
    • EPG4 antibody
    • Etoposide induced 2.4 mRNA antibody
    • Etoposide-induced protein 2.4 homolog antibody
    • p53-induced gene 8 protein antibody
    • PIG8 antibody
    • TP53I8 antibody
    • Tumor protein p53 inducible protein 8 antibody
    see all

图片

  • Lane 1 : Anti-EI24 antibody (ab117463) at 1 µg/ml
    Lane 2 : Anti-EI24 antibody (ab117463) at 2 µg/ml

    Lane 1 : Rat liver tissue lysate
    Lane 2 : Rat liver tissue lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 39 kDa
  • Immunohistochemistry of EI24 in rat liver tissue with ab117463 at 5 ug/mL.

文献

ab117463 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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