概述

  • 产品名称Anti-EFTUD2抗体
    参阅全部 EFTUD2 一抗
  • 描述
    兔多克隆抗体to EFTUD2
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Dog, Turkey, Pig, Xenopus laevis, Caenorhabditis elegans, Chimpanzee, Zebrafish, Rhesus monkey, Gorilla, Orangutan, Xenopus tropicalis
  • 免疫原

    Synthetic peptide corresponding to a region between residues 1 and 50 of human EFTUD2 (NP_004238.2).

  • 阳性对照
    • Human laryngeal squamous cell carcinoma; mouse squamous cell carcinoma.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab84501 was affinity purified using an epitope specific to EFTUD2 immobilized on solid support.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab84501 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: 1/100 - 1/500.
    Epitope exposure is recommended.
    Epitope exposure with citrate buffer will enhance staining.

    Likely to work with frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Component of the U5 snRNP complex required for pre-mRNA splicing. Binds GTP.
    • 疾病相关Defects in EFTUD2 are the cause of mandibulofacial dysostosis with microcephaly (MFDM) [MIM:610536]. A rare syndrome characterized by progressive microcephaly, midface and malar hypoplasia, micrognathia, microtia, dysplastic ears, preauricular skin tags, significant developmental delay, and speech delay. Many patients have major sequelae, including choanal atresia that results in respiratory difficulties, conductive hearing loss, and cleft palate.
    • 序列相似性Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
    • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 116 kDa antibody
      • 116 kDa U5 small nuclear ribonucleoprotein component antibody
      • EFTUD2 antibody
      • Elongation factor Tu GTP binding domain containing 2 antibody
      • Elongation factor Tu GTP-binding domain-containing protein 2 antibody
      • hSNU114 antibody
      • MFDGA antibody
      • MFDM antibody
      • SNRNP116 antibody
      • Snrp116 antibody
      • Snu114 antibody
      • SNU114 homolog antibody
      • U5 116KD antibody
      • U5 small nuclear ribonucleoprotein component antibody
      • U5 snRNP specific protein, 116 kD antibody
      • U5 snRNP specific protein, 116 kDa antibody
      • U5 snRNP-specific protein antibody
      • U5-116 kDa antibody
      • U5-116KD antibody
      • U5S1_HUMAN antibody
      see all

    Anti-EFTUD2 antibody 图像

    • Staining of EFTUD2 by Immunohistochemistry on a formalin fixed, paraffin embedded section of human laryngeal squamous cell carcinoma using a 1/100 dilution of ab84501.
      Detection: DAB staining.
    • Staining of EFTUD2 by Immunohistochemistry on a formalin fixed, paraffin embedded section of mouse squamous cell carcinoma using a 1/100 dilution of ab84501.
      Detection: DAB staining.

    Anti-EFTUD2 antibody (ab84501)参考文献

    ab84501 has not yet been referenced specifically in any publications.

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