概述

  • 产品名称Anti-EFHC1抗体
    参阅全部 EFHC1 一抗
  • 描述
    兔多克隆抗体to EFHC1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Full length protein, corresponding to amino acids 1-640 of Human EFHC1 (AAH20210.1).

  • 阳性对照
    • Mouse testis; EFHC1 transfected 293T cell line lysate

性能

应用

Our Abpromise guarantee covers the use of ab103824 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 74 kDa.

靶标

  • 功能Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration (PubMed:22926142). May enhance calcium influx through CACNA1E and stimulate programmed cell death (PubMed:15258581).
  • 组织特异性Widely expressed. Not detected in lymphocytes.
  • 疾病相关Juvenile myoclonic epilepsy 1
    Juvenile absence epilepsy 1
    Mutation Leu-229 may be a cause of intractable epilepsy of infancy. Affected individuals have seizures of multiple type, manifested as tonic, clonic, and myoclonic seizures in the neonatal period, and as tonic seizures activated frequently by sleep, and repeated frequent myoclonic seizures in later infancy. The seizures are unresponsive to numerous antiepileptic drugs, and infants die in the first years of life. Although heterozygosity for Leu-229 has been associated with relatively benign forms of epilepsy in adolescence, homozygosity for the same mutation has much more severe consequences.
  • 序列相似性Contains 3 DM10 domains.
    Contains 1 EF-hand domain.
  • 细胞定位Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle.
  • Information by UniProt
  • 数据库链接
  • 别名
    • EF hand domain (C terminal) containing 1 antibody
    • EF hand domain containing protein 1 antibody
    • EF-hand domain-containing protein 1 antibody
    • Efhc1 antibody
    • EFHC1_HUMAN antibody
    • EJA1 antibody
    • EJM1 antibody
    • FLJ10466 antibody
    • FLJ37290 antibody
    • JAE antibody
    • Myoclonin 1 antibody
    • Myoclonin-1 antibody
    see all

Anti-EFHC1 antibody 图像

  • Anti-EFHC1 antibody (ab103824) at 5 µg/ml + Mouse testis tissue lysate at 50 µg

    Predicted band size : 74 kDa
  • All lanes : Anti-EFHC1 antibody (ab103824) at 5 µg/ml

    Lane 1 : EFHC1 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 74 kDa

Anti-EFHC1 antibody (ab103824)参考文献

ab103824 has not yet been referenced specifically in any publications.

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