概述

  • 产品名称Anti-EFEMP1抗体
    参阅全部 EFEMP1 一抗
  • 描述
    兔多克隆抗体to EFEMP1
  • 特异性This antibody detects a strong 62 kDa EFEMP1 protein in human RPE cell extracts. The antibody does not cross-react with any other protein in RPE cells.
  • 经测试应用适用于: WB, IPmore details
  • 种属反应性
    与反应: Rat, Human
  • 免疫原

    Synthetic peptide:

    TYTQCTDGYEWDPVRQQC

    , corresponding to N terminal amino acids 25-42 of Human EFEMP1.

  • 阳性对照
    • Human RPE cell extracts.
  • 常规说明

    Storage of very dilute antibody solutions is not recommended, unless they are prepared in specially formulated multi use antibody dilution buffer. Positive control available as ab169709.

性能

应用

Our Abpromise guarantee covers the use of ab14926 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500. Detects a band of approximately 62 kDa (predicted molecular weight: 60 kDa).
IP 1/200.

靶标

  • 功能Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.
  • 组织特异性In the eye, associated with photoreceptor outer and inner segment regions, the nerve fiber layer, outer nuclear layer and inner and outer plexiform layers of the retina.
  • 疾病相关Defects in EFEMP1 are a cause of Doyne honeycomb retinal dystrophy (DHRD) [MIM:126600]; also known as malattia leventinese (MLVT) (ML). DHRD is an autosomal dominant disease characterized by yellow-white deposits known as drusen that accumulate beneath the retinal pigment epithelium.
  • 序列相似性Belongs to the fibulin family.
    Contains 6 EGF-like domains.
  • 细胞定位Secreted > extracellular space. Secreted > extracellular space > extracellular matrix. Localizes to the lamina propria underneath the olfactory epithelium.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DHRD antibody
    • Doyne honeycomb retinal degeneration antibody
    • DRAD antibody
    • EFEMP 1 antibody
    • EFEMP1 antibody
    • EGF containing fibulin like extracellular matrix protein 1 antibody
    • EGF containing fibulin like extracellular matrix protein 1 precursor antibody
    • EGF-containing fibulin-like extracellular matrix protein 1 antibody
    • Epidermal growth factor containing fibulin like extracellular matrix protein 1 antibody
    • Extracellular protein S1 5 antibody
    • Extracellular protein S1-5 antibody
    • FBLN 3 antibody
    • FBLN3 antibody
    • FBLN3_HUMAN antibody
    • FBNL antibody
    • FIBL 3 antibody
    • FIBL-3 antibody
    • FIBL3 antibody
    • Fibrillin like antibody
    • Fibrillin like protein antibody
    • Fibrillin-like protein antibody
    • FIBULIN 3 antibody
    • Fibulin-3 antibody
    • Fibulin3 antibody
    • FLJ35535 antibody
    • Heat shock 70 KD protein 1 antibody
    • MGC111353 antibody
    • MLVT antibody
    • MTLV antibody
    • S1 5 antibody
    • T16 protein antibody
    see all

Anti-EFEMP1 antibody (ab14926)参考文献

This product has been referenced in:
  • Yang T  et al. Epigenetic inactivation of EFEMP1 is associated with tumor suppressive function in endometrial carcinoma. PLoS One 8:e67458 (2013). WB, IHC ; Human . Read more (PubMed: 23840707) »
  • Camaj P  et al. EFEMP1 binds the EGF receptor and activates MAPK and Akt pathways in pancreatic carcinoma cells. Biol Chem 390:1293-302 (2009). WB . Read more (PubMed: 19804359) »

See all 2 Publications for this product

Product Wall

This antibody is in an antibody stabilization buffer. This buffer mainly contains:

- Tris/glycine buffer pH 7.4-7.8
- Cryo-protective agents
- Stabilizing proteins (BSA)
- Glycerol

0.02% sodium azide is also present...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"