Anti-EFEMP1抗体(ab106429)

概述

  • 产品名称Anti-EFEMP1抗体
    参阅全部 EFEMP1 一抗
  • 描述
    兔多克隆抗体to EFEMP1
  • 特异性ab106429 is predicted not to cross-react with other Fibulin proteins.
  • 经测试应用适用于: ICC/IF, WB, ICCmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to Human EFEMP1 (C terminal).
    Database link: Q12805

  • 阳性对照
    • HeLa cell lysate.
  • 常规说明

    Antibodies should not be exposed to prolonged high temperatures.

性能

应用

Our Abpromise guarantee covers the use of ab106429 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 55 kDa.
ICC Use a concentration of 20 µg/ml.

靶标

  • 功能Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.
  • 组织特异性In the eye, associated with photoreceptor outer and inner segment regions, the nerve fiber layer, outer nuclear layer and inner and outer plexiform layers of the retina.
  • 疾病相关Defects in EFEMP1 are a cause of Doyne honeycomb retinal dystrophy (DHRD) [MIM:126600]; also known as malattia leventinese (MLVT) (ML). DHRD is an autosomal dominant disease characterized by yellow-white deposits known as drusen that accumulate beneath the retinal pigment epithelium.
  • 序列相似性Belongs to the fibulin family.
    Contains 6 EGF-like domains.
  • 细胞定位Secreted > extracellular space. Secreted > extracellular space > extracellular matrix. Localizes to the lamina propria underneath the olfactory epithelium.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DHRD antibody
    • Doyne honeycomb retinal degeneration antibody
    • DRAD antibody
    • EFEMP 1 antibody
    • EFEMP1 antibody
    • EGF containing fibulin like extracellular matrix protein 1 antibody
    • EGF containing fibulin like extracellular matrix protein 1 precursor antibody
    • EGF-containing fibulin-like extracellular matrix protein 1 antibody
    • Epidermal growth factor containing fibulin like extracellular matrix protein 1 antibody
    • Extracellular protein S1 5 antibody
    • Extracellular protein S1-5 antibody
    • FBLN 3 antibody
    • FBLN3 antibody
    • FBLN3_HUMAN antibody
    • FBNL antibody
    • FIBL 3 antibody
    • FIBL-3 antibody
    • FIBL3 antibody
    • Fibrillin like antibody
    • Fibrillin like protein antibody
    • Fibrillin-like protein antibody
    • FIBULIN 3 antibody
    • Fibulin-3 antibody
    • Fibulin3 antibody
    • FLJ35535 antibody
    • Heat shock 70 KD protein 1 antibody
    • MGC111353 antibody
    • MLVT antibody
    • MTLV antibody
    • S1 5 antibody
    • T16 protein antibody
    see all

Anti-EFEMP1 antibody 图像

  • Lane 1 : Anti-EFEMP1 antibody (ab106429) at 0.5 µg/ml
    Lane 2 : Anti-EFEMP1 antibody (ab106429) at 1 µg/ml

    Lane 1 : HeLa cell lysate
    Lane 2 : HeLa cell lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 55 kDa
  • Immunohistochemical analysis of HeLa cells labelling EFEMP1 with ab106429 at 20 µg/ml. 

  • Immunofluorescence analysis of Hela cells labelling Fibulin 3 with ab106429 at 20 ug/ml.

Anti-EFEMP1 antibody (ab106429)参考文献

ab106429 has not yet been referenced specifically in any publications.

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