The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/100 - 1/500. Detects a band of approximately 42 kDa (predicted molecular weight: 42 kDa).
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.
Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver.
Belongs to the G-protein coupled receptor 1 family.
Benamer N et al. Electrophysiological and functional effects of sphingosine-1-phosphate in mouse ventricular fibroblasts. Biochem Biophys Res Commun408:6-11 (2011).
Read more (PubMed: 21420933) »
Illuzzi G et al. Sphingosine kinase mediates resistance to the synthetic retinoid N-(4-hydroxyphenyl)retinamide in human ovarian cancer cells. J Biol Chem285:18594-602 (2010).
Read more (PubMed: 20404323) »