Anti-EDG2 /LPA-1抗体(ab23698)
Key features and details
- Rabbit polyclonal to EDG2 /LPA-1
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-EDG2 /LPA-1抗体
参阅全部 EDG2 /LPA-1 一抗 -
描述
兔多克隆抗体to EDG2 /LPA-1 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse, Rat, Human
预测可用于: Xenopus laevis -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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阳性对照
- WB: Mouse liver, A549 cell lysate, Rat Liver lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, PBS -
Concentration information loading...
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纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab23698于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/200. Detects a band of approximately 43 kDa (predicted molecular weight: 41 kDa).
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说明 |
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WB
1/200. Detects a band of approximately 43 kDa (predicted molecular weight: 41 kDa). |
靶标
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功能
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation. -
组织特异性
Expressed in many adult organs, including brain, heart, colon, small intestine, placenta, prostate, ovary, pancreas, testes, spleen, skeletal muscle, and kidney. Little or no expression in liver, lung, thymus, or peripheral blood leukocytes. -
序列相似性
Belongs to the G-protein coupled receptor 1 family. -
细胞定位
Cell surface. Cell membrane. Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA co-localizes with RALA in the endocytic vesicles. - Information by UniProt
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数据库链接
- Entrez Gene: 1902 Human
- Entrez Gene: 14745 Mouse
- Entrez Gene: 116744 Rat
- Omim: 602282 Human
- SwissProt: Q92633 Human
- SwissProt: P61793 Mouse
- SwissProt: P61794 Rat
- Unigene: 126667 Human
see all -
别名
- 5031439C20 antibody
- AI326300 antibody
- EDG 2 antibody
see all
图片
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (15)
ab23698 被引用在 15 文献中.
- Ahmadzai MM et al. LPAR1 regulates enteric nervous system function through glial signaling and contributes to chronic intestinal pseudo-obstruction. J Clin Invest 132:N/A (2022). PubMed: 35166239
- Grubišić V & Gulbransen BD Astrocyte Cell Surface Antigen 2 and Other Potential Cell Surface Markers of Enteric glia in the Mouse Colon. ASN Neuro 14:17590914221083203 (2022). PubMed: 35593118
- Kim D et al. Lysophosphatidic Acid Mediates Imiquimod-Induced Psoriasis-like Symptoms by Promoting Keratinocyte Proliferation through LPAR1/ROCK2/PI3K/AKT Signaling Pathway. Int J Mol Sci 22:N/A (2021). PubMed: 34639115
- Lee R et al. Effect of the Gintonin-Enriched Fraction on Glucagon-Like-Protein-1 Release. Molecules 26:N/A (2021). PubMed: 34684879
- Wu XP et al. microRNA-329 reduces bone cancer pain through the LPAR1-dependent LPAR1/ERK signal transduction pathway in mice. Ther Adv Med Oncol 11:1758835919875319 (2019). PubMed: 31692673