Anti-S1P1/EDG1抗体(ab137467)
Key features and details
- Rabbit polyclonal to S1P1/EDG1
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-S1P1/EDG1抗体
参阅全部 S1P1/EDG1 一抗 -
描述
兔多克隆抗体to S1P1/EDG1 -
宿主
Rabbit -
经测试应用
适用于: WB, IHC-Pmore details -
种属反应性
与反应: Mouse, Human -
免疫原
Synthetic peptide corresponding to S1P1/EDG1 aa 303-382.
Sequence:NSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSR SKSDNSSHPQKDEGDNPETIMSSGNVNSSS
Database link: P21453 -
阳性对照
- HepG2 whole cell lysate, mouse brain tissue
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 79.99% PBS, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab137467于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 43 kDa.
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IHC-P |
1/100 - 1/1000.
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说明 |
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WB
1/500 - 1/3000. Predicted molecular weight: 43 kDa. |
IHC-P
1/100 - 1/1000. |
靶标
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功能
Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. This inducible epithelial cell G-protein-coupled receptor may be involved in the processes that regulate the differentiation of endothelial cells. Seems to be coupled to the G(i) subclass of heteromeric G proteins. -
组织特异性
Endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin. -
序列相似性
Belongs to the G-protein coupled receptor 1 family. -
翻译后修饰
S1P-induced endothelial cell migration requires the PKB/AKT1-mediated phosphorylation of the third intracellular loop at the Thr-236 residue. -
细胞定位
Cell membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 1901 Human
- Entrez Gene: 13609 Mouse
- Omim: 601974 Human
- SwissProt: P21453 Human
- SwissProt: O08530 Mouse
- Unigene: 154210 Human
- Unigene: 982 Mouse
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别名
- CD363 antibody
- CHEDG 1 antibody
- CHEDG1 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (3)
ab137467 被引用在 3 文献中.
- Patrone M et al. Combinatorial allosteric modulation of agonist response in a self-interacting G-protein coupled receptor. Commun Biol 3:27 (2020). PubMed: 31941999
- Hiramatsu-Asano S et al. Deletion of Mir223 Exacerbates Lupus Nephritis by Targeting S1pr1 in Faslpr/lpr Mice. Front Immunol 11:616141 (2020). PubMed: 33574820
- Christensen PM et al. Impaired endothelial barrier function in apolipoprotein M-deficient mice is dependent on sphingosine-1-phosphate receptor 1. FASEB J 30:2351-9 (2016). PubMed: 26956418