概述

  • 产品名称Anti-EDD抗体
    参阅全部 EDD 一抗
  • 描述
    兔多克隆抗体to EDD
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rat, Horse, Chicken, Cow, Dog, Turkey, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Xenopus tropicalis , Platypus (Ornithorhynchus anatinus)
  • 免疫原

    Synthetic peptide corresponding to a region between residues 600 and 650 of human (NP_056986.2)

  • 阳性对照
    • Human breast adenocarcinoma tissue.

性能

应用

Our Abpromise guarantee covers the use of ab84135 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: 1/100 - 1/500.
    Epitope exposure with citrate buffer will enhance staining.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific amino-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). May be involved in maturation and/or transcriptional regulation of mRNA. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development.
    • 组织特异性Widely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney.
    • 通路Protein modification; protein ubiquitination.
    • 序列相似性Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
      Contains 1 PABC domain.
      Contains 1 UBR-type zinc finger.
    • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 4432411E13Rik antibody
      • AW549941 antibody
      • C77315 antibody
      • D030042K14 antibody
      • DD5 antibody
      • E3 identified by differential display antibody
      • E3 ubiquitin protein ligase, HECT domain containing, 1 antibody
      • E3 ubiquitin-protein ligase antibody
      • E3 ubiquitin-protein ligase UBR5 antibody
      • EDD 1 antibody
      • EDD antibody
      • EDD1 antibody
      • FLJ11310 antibody
      • HECT domain-containing 1 antibody
      • hHYD antibody
      • HYD antibody
      • Hyperplastic discs protein homolog antibody
      • Hyperplastic discs, Drosophila, homolog of antibody
      • KIAA0896 antibody
      • MGC57263 antibody
      • mKIAA0896 antibody
      • Progestin induced protein antibody
      • Progestin-induced protein antibody
      • Rat100 antibody
      • Ubiquitin protein ligase antibody
      • Ubiquitin protein ligase E3 component n recognin 5 antibody
      • UBR5 antibody
      • UBR5_HUMAN antibody
      see all

    Anti-EDD antibody 图像

    • ab84135 at 1/100 dilution staining EDD in human breast adenocarcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.

    Anti-EDD antibody (ab84135)参考文献

    ab84135 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab84135.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"