概述

  • 产品名称Anti-EDARADD抗体
  • 描述
    兔多克隆抗体to EDARADD
  • 经测试应用适用于: ICC/IF, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    antigen sequence: PTISDLLNDQ DLLDVIRIKL DPCHPTVKNW RNFASKWGMS YDELCFLEQR PQSPTLEFLL RNSQRTVGQL MELCRLYHRA DVEKVLRRWV DEEWPKRERG DP, corresponding to amino acids 110-211 of Human EDARADD

  • 阳性对照
    • Human duodenum tissue.

性能

应用

Our Abpromise guarantee covers the use of ab121581 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use a concentration of 1 - 4 µg/ml.

Recommend PFA Fixation and Triton X-100 treatment

IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Use buffer at pH 6 for antigen retrieval.

靶标

  • 功能Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF-kappa-B.
  • 组织特异性Detected in adult pancreas, placenta and fetal skin, and at lower levels in lung, thymus, prostate and testis.
  • 疾病相关Defects in EDARADD are a cause of ectodermal dysplasia anhidrotic (EDA) [MIM:224900]; also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDA is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands.
  • 序列相似性Contains 1 death domain.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cr antibody
    • Crinkled homolog antibody
    • ectodysplasia A receptor associated death domain antibody
    • Ectodysplasin-A receptor-associated adapter protein antibody
    • ED3 antibody
    • EDA3 antibody
    • EDAD_HUMAN antibody
    • EDAR associated death domain antibody
    • EDAR-associated death domain protein antibody
    • EDARADD antibody
    • Protein crinkled homolog antibody
    see all

Anti-EDARADD antibody 图像

  • Immunofluorescent staining of Human cell line A-431 shows positivity in nucleus but not nucleoli and cytoplasm. Recommended concentration of ab121581 1-4 µg/ml. Cells treated with PFA/Triton X-100.
  • ab121581 at a 1/75 dilution, staining EDARADD in glandular cells of paraffin-embedded Human duodenum tissue by immunohistochemistry.

Anti-EDARADD antibody (ab121581)参考文献

ab121581 has not yet been referenced specifically in any publications.

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