概述

  • 产品名称Anti-EDAR抗体
    参阅全部 EDAR 一抗
  • 描述
    兔多克隆抗体to EDAR
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region of Human EDAR

  • 阳性对照
    • Placenta lysate

性能

应用

Our Abpromise guarantee covers the use of ab76399 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 49 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
ELISA Use at an assay dependent concentration.

Titre using peptide based assay, 1:12500.

靶标

  • 功能Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death.
  • 组织特异性Detected in fetal kidney, lung, skin and cultured neonatal epidermal keratinocytes. Not detected in lymphoblast and fibroblast cell lines.
  • 疾病相关Defects in EDAR are a cause of ectodermal dysplasia anhidrotic (EDA) [MIM:224900]; also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDA is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands.
    Defects in EDAR are the cause of ectodermal dysplasia type 3 (ED3) [MIM:129490]; also known as ectodermal dysplasia hypohidrotic autosomal dominant or EDA3. ED3 is an autosomal dominant condition characterized by hypotrichosis, abnormal or missing teeth, and hypohidrosis due to the absence of sweat glands.
  • 序列相似性Contains 1 death domain.
    Contains 3 TNFR-Cys repeats.
  • 发展阶段Found in craniofacial tissues from embryonic day 42-53. Expressed in fetal skin 11 and 15 weeks after gestation.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Anhidrotic ectodysplasin receptor 1 antibody
    • DL antibody
    • Downless (mouse) homolog antibody
    • Downless homolog antibody
    • Downless mouse homolog of antibody
    • ECTD10A antibody
    • ECTD10B antibody
    • Ectodermal dysplasia receptor antibody
    • Ectodysplasin 1 anhidrotic receptor antibody
    • Ectodysplasin A receptor antibody
    • Ectodysplasin A1 isoform receptor antibody
    • Ectodysplasin-A receptor antibody
    • ED 1R antibody
    • ED 3 antibody
    • ED 5 antibody
    • ED1R antibody
    • ED3 antibody
    • ED5 antibody
    • EDA 1R antibody
    • EDA 3 antibody
    • EDA A1 receptor antibody
    • EDA A1R antibody
    • EDA-A1 receptor antibody
    • EDA1R antibody
    • EDA3 antibody
    • Edar antibody
    • EDAR_HUMAN antibody
    • HRM1 antibody
    • Tumor necrosis factor receptor superfamily member EDAR antibody
    see all

Anti-EDAR antibody 图像

  • Anti-EDAR antibody (ab76399) at 1 µg/ml (in 5% skim milk / PBS buffer) + Placenta lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 49 kDa

Anti-EDAR antibody (ab76399)参考文献

ab76399 has not yet been referenced specifically in any publications.

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