概述

  • 产品名称Anti-EDAR抗体
    参阅全部 EDAR 一抗
  • 描述
    小鼠单克隆抗体to EDAR
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 64-179 of Human EDAR

性能

应用

Our Abpromise guarantee covers the use of ab56803 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death.
    • 组织特异性Detected in fetal kidney, lung, skin and cultured neonatal epidermal keratinocytes. Not detected in lymphoblast and fibroblast cell lines.
    • 疾病相关Defects in EDAR are a cause of ectodermal dysplasia anhidrotic (EDA) [MIM:224900]; also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDA is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands.
      Defects in EDAR are the cause of ectodermal dysplasia type 3 (ED3) [MIM:129490]; also known as ectodermal dysplasia hypohidrotic autosomal dominant or EDA3. ED3 is an autosomal dominant condition characterized by hypotrichosis, abnormal or missing teeth, and hypohidrosis due to the absence of sweat glands.
    • 序列相似性Contains 1 death domain.
      Contains 3 TNFR-Cys repeats.
    • 发展阶段Found in craniofacial tissues from embryonic day 42-53. Expressed in fetal skin 11 and 15 weeks after gestation.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Anhidrotic ectodysplasin receptor 1 antibody
      • DL antibody
      • Downless (mouse) homolog antibody
      • Downless homolog antibody
      • Downless mouse homolog of antibody
      • ECTD10A antibody
      • ECTD10B antibody
      • Ectodermal dysplasia receptor antibody
      • Ectodysplasin 1 anhidrotic receptor antibody
      • Ectodysplasin A receptor antibody
      • Ectodysplasin A1 isoform receptor antibody
      • Ectodysplasin-A receptor antibody
      • ED 1R antibody
      • ED 3 antibody
      • ED 5 antibody
      • ED1R antibody
      • ED3 antibody
      • ED5 antibody
      • EDA 1R antibody
      • EDA 3 antibody
      • EDA A1 receptor antibody
      • EDA A1R antibody
      • EDA-A1 receptor antibody
      • EDA1R antibody
      • EDA3 antibody
      • Edar antibody
      • EDAR_HUMAN antibody
      • HRM1 antibody
      • Tumor necrosis factor receptor superfamily member EDAR antibody
      see all

    Anti-EDAR antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab56803 EDAR antibody at 1ug/ml. Predicted band size of immunogen is 39 kDa

    Anti-EDAR antibody (ab56803)参考文献

    ab56803 has not yet been referenced specifically in any publications.

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