Anti-EDA抗体- Aminoterminal end (ab64748)

概述

  • 产品名称
    Anti-EDA抗体- Aminoterminal end
    参阅全部 EDA 一抗
  • 描述
    兔多克隆抗体to EDA - Aminoterminal end
  • 特异性
    This antibody reacts with EDA
  • 经测试应用
    适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    This information is considered to be commercially sensitive.

  • 阳性对照
    • Hela cell line lysates

性能

应用

Our Abpromise guarantee covers the use of ab64748 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/50 - 1/100. Detects a band of approximately 42 kDa (predicted molecular weight: 42 kDa).
ELISA 1/1000.

靶标

  • 功能
    Seems to be involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Isoform 1 binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor XEDAR.
  • 组织特异性
    Not abundant; expressed in specific cell types of ectodermal (but not mesodermal) origin of keratinocytes, hair follicles, sweat glands. Also in adult heart, liver, muscle, pancreas, prostate, fetal liver, uterus, small intestine and umbilical chord.
  • 疾病相关
    Defects in EDA are the cause of ectodermal dysplasia type 1 (ED1) [MIM:305100]; also known as Christ-Siemens-Touraine syndrome or X-linked hypohidrotic ectodermal dysplasia (XLHED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. ED1 is a disease characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. ED1 is the most common form of over 150 clinically distinct ectodermal dysplasias.
    Defects in EDA are the cause of tooth agenesis selective X-linked type 1 (STHAGX1) [MIM:313500]. A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth).
  • 序列相似性
    Belongs to the tumor necrosis factor family.
    Contains 1 collagen-like domain.
  • 翻译后修饰
    N-glycosylated.
    Processing by furin produces a secreted form.
  • 细胞定位
    Secreted and Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ECTD1 antibody
    • Ectodermal dysplasia 1, anhidrotic antibody
    • Ectodermal dysplasia protein antibody
    • Ectodermal dysplasia, anhidrotic (hypohydrotic) antibody
    • Ectodysplasin A antibody
    • Ectodysplasin A, membrane form antibody
    • Ectodysplasin A, secreted form antibody
    • ECTODYSPLASIN A1 ISOFORM antibody
    • ECTODYSPLASIN A2 ISOFORM antibody
    • ECTODYSPLASIN antibody
    • Ectodysplasin-A antibody
    • ED1 A1 antibody
    • ED1 A2 antibody
    • ED1 antibody
    • ED1 GENE antibody
    • Eda A1 antibody
    • Eda A2 antibody
    • eda antibody
    • EDA protein antibody
    • EDA protein homolog antibody
    • EDA_HUMAN antibody
    • EDA1 antibody
    • EDA1 GENE antibody
    • EDA2 antibody
    • HED antibody
    • HED1 antibody
    • ODT1 antibody
    • Oligodontia 1 antibody
    • secreted form antibody
    • STHAGX1 antibody
    • Ta antibody
    • Tabby antibody
    • Tabby protein antibody
    • X linked anhidroitic ectodermal dysplasia protein antibody
    • XHED antibody
    • XLHED antibody
    see all

图片

  • Anti-EDA antibody - Aminoterminal end (ab64748) at 1/60 dilution + Hela cell line lysates at 35 µg

    Predicted band size : 42 kDa
    Observed band size : 42 kDa

实验方案

文献

ab64748 has not yet been referenced specifically in any publications.

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