概述

  • 产品名称Anti-EBV LMP2A抗体[15F9]
    参阅全部 EBV LMP2A 一抗
  • 描述
    大鼠单克隆抗体[15F9] to EBV LMP2A
  • 特异性ab59028 recognises LMP2A and does not cross react with LMP2B.
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    Reacts with Epstein Barr Virus.
  • 免疫原

    Bacterial TrpE-LMP2A fusion protein

  • 阳性对照
    • Hodgkin’s Disease

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • 纯度Protein G purified
  • 纯化说明Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
  • 克隆单克隆
  • 克隆编号15F9
  • 骨髓瘤P3x63-Ag8.653
  • 同种型IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab59028 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/1000.
IHC-P Use at an assay dependent dilution.

靶标

  • 相关性Epstein Barr virus (EBV) is a member of the herpesvirus family and one of the most common human viruses. Most people become infected with EBV during their lives. Primary infections usually results in infectious mononucleosis (glandular fever) but the virus can also lay dormant in B lymphocytes and when reactivated become associated with more serious disease such as Burkitt's lymphoma, nasopharyngeal carcinoma and Hodgkin's disease. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.
  • 别名
    • EBV latent membrane protein 2A antibody
    • Epstein Barr virus antibody
    • HHV4 antibody
    • Human Herpesvirus 4 antibody
    • Latent membrane protein 2 antibody
    • LMP2 antibody
    • Terminal protein antibody
    see all

Anti-EBV LMP2A antibody [15F9] (ab59028)参考文献

This product has been referenced in:
  • Cohen M  et al. Epstein-Barr virus presence in pediatric diffuse large B-cell lymphoma reveals a particular association and latency patterns: analysis of viral role in tumor microenvironment. Int J Cancer 132:1572-80 (2013). Read more (PubMed: 22987474) »
  • Vincent-Bugnas S  et al. EBV infection is common in gingival epithelial cells of the periodontium and worsens during chronic periodontitis. PLoS One 8:e80336 (2013). IHC-P . Read more (PubMed: 24367478) »

See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"