概述

  • 产品名称
    Anti-EBV LMP2A抗体[15F9]
    参阅全部 EBV LMP2A 一抗
  • 描述
    大鼠单克隆抗体[15F9] to EBV LMP2A
  • 特异性
    ab59028 recognises LMP2A and does not cross react with LMP2B.
  • 经测试应用
    适用于: WB, IHC-Pmore details
  • 种属反应性
    Reacts with Epstein Barr Virus.
  • 免疫原

    Bacterial TrpE-LMP2A fusion protein

  • 阳性对照
    • Hodgkin’s Disease

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • 存储溶液
    Preservative: 0.09% Sodium Azide
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • 纯度
    Protein G purified
  • 纯化说明
    Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
  • 克隆
    单克隆
  • 克隆编号
    15F9
  • 骨髓瘤
    P3x63-Ag8.653
  • 同种型
    IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab59028 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/1000.
IHC-P Use at an assay dependent dilution.

靶标

  • 相关性
    Epstein Barr virus (EBV) is a member of the herpesvirus family and one of the most common human viruses. Most people become infected with EBV during their lives. Primary infections usually results in infectious mononucleosis (glandular fever) but the virus can also lay dormant in B lymphocytes and when reactivated become associated with more serious disease such as Burkitt's lymphoma, nasopharyngeal carcinoma and Hodgkin's disease. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.
  • 别名
    • EBV latent membrane protein 2A antibody
    • Epstein Barr virus antibody
    • HHV4 antibody
    • Human Herpesvirus 4 antibody
    • Latent membrane protein 2 antibody
    • LMP2 antibody
    • Terminal protein antibody
    see all

文献

This product has been referenced in:
  • Quan L  et al. PD-1 Blockade Can Restore Functions of T-Cells in Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma In Vitro. PLoS One 10:e0136476 (2015). IHC-P ; Human . Read more (PubMed: 26361042) »
  • Cohen M  et al. Epstein-Barr virus presence in pediatric diffuse large B-cell lymphoma reveals a particular association and latency patterns: analysis of viral role in tumor microenvironment. Int J Cancer 132:1572-80 (2013). Read more (PubMed: 22987474) »

See all 4 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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