Anti-EBV LMP2A抗体[14B7] (ab59026)


  • 产品名称Anti-EBV LMP2A抗体[14B7]
    参阅全部 EBV LMP2A 一抗
  • 描述
    大鼠单克隆抗体[14B7] to EBV LMP2A
  • 特异性ab59026 is specific for Epstein-Barr virus LMP2A. Clone 14B7 detects wild-type LMP2A protein.
  • 经测试应用适用于: WB, IP, ICC/IFmore details
    不适用于: IHC-P
  • 种属反应性
    Epstein-Barr virus
  • 免疫原

    Bacterial TrpE-LMP2A fusion protein


  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆单克隆
  • 克隆编号14B7
  • 骨髓瘤P3x63-Ag8.653
  • 同种型IgG2a
  • 研究领域


Our Abpromise guarantee covers the use of ab59026 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/1000. Detects a band of approximately 50 kDa.
IP Use at an assay dependent dilution.
ICC/IF Use at an assay dependent dilution.
  • 应用说明Is unsuitable for IHC-P.
  • 靶标

    • 相关性Epstein Barr virus (EBV) is a member of the herpesvirus family and one of the most common human viruses. Most people become infected with EBV during their lives. Primary infections usually results in infectious mononucleosis (glandular fever) but the virus can also lay dormant in B lymphocytes and when reactivated become associated with more serious disease such as Burkitt's lymphoma, nasopharyngeal carcinoma and Hodgkin's disease. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.
    • 别名
      • EBV latent membrane protein 2A antibody
      • Epstein Barr virus antibody
      • HHV4 antibody
      • Human Herpesvirus 4 antibody
      • Latent membrane protein 2 antibody
      • LMP2 antibody
      • Terminal protein antibody
      see all

    Anti-EBV LMP2A antibody [14B7] (ab59026)参考文献

    This product has been referenced in:
    • Minamitani T  et al. Evasion of affinity-based selection in germinal centers by Epstein-Barr virus LMP2A. Proc Natl Acad Sci U S A 112:11612-7 (2015). WB ; Mouse . Read more (PubMed: 26305967) »
    • Marquitz AR  et al. Expression profile of microRNAs in Epstein-Barr virus-infected AGS gastric carcinoma cells. J Virol 88:1389-93 (2014). WB . Read more (PubMed: 24227849) »

    See all 6 Publications for this product

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    Abcam guarantees this product to work in the species/application used in this Abreview.
    Application Western blot
    Sample Human Cell lysate - whole cell (B cell)
    Loading amount 10 µg
    Specification B cell
    Gel Running Conditions Reduced Denaturing (10%)
    Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 22°C

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    Verified customer

    提交于 Jun 21 2010

    Thank you for your enquiry. The size of protein detected can vary from 45 kDa to around 66 kDa depending on the level of phosphorylation. Unfortunately we do not have any WB images available but the two papers below using the same clone, will provi...

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