功能May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.
组织特异性Expressed in different tumor cell lines. Up-regulated in activated B- and T-lymphocytes.
序列相似性Belongs to the MAPRE family. Contains 1 CH (calponin-homology) domain. Contains 1 EB1 C-terminal domain.
结构域Composed of two functionally independent domains. The N-terminal domain forms an hydrophobic cleft involved in microtubule binding and the C-terminal is involved in the formation of mutually exclusive complexes with APC and DCTN1.
细胞定位Cytoplasm > cytoskeleton. Associated with the microtubule network. Accumulates at the plus end of microtubules.
H.sapiens mRNA for novel T cell activation protein antibody
Microtubule associated protein RP/EB family member 2 antibody
Microtubule-associated protein RP/EB family member 2 antibody
T cell activation protein EB1 family antibody
Anti-EB2 antibody 图像
Western blot - Anti-EB2 antibody (ab123579)
Anti-EB2 antibody (ab123579) at 1/100 dilution + CEM cell line lysate at 35 µg
Predicted band size : 37 kDa
Anti-EB2 antibody (ab123579)参考文献
This product has been referenced in:
Nakamura S et al. Dissecting the nanoscale distributions and functions of microtubule-end-binding proteins EB1 and ch-TOG in interphase HeLa cells. PLoS One7:e51442 (2012).
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