概述

  • 产品名称Anti-EAAT3抗体[4D6.2]
    参阅全部 EAAT3 一抗
  • 描述
    小鼠单克隆抗体[4D6.2] to EAAT3
  • 经测试应用适用于: WB, IHC-Frmore details
  • 种属反应性
    与反应: Rat
    预测可用于: Mouse, Rabbit, Cow, Human
  • 免疫原

    Synthetic peptide:

    K-DKSDTISFTQTSQF

    , corresponding to C terminal amino acids 510-523 of Rat EAAT3

  • 阳性对照
    • Rat cerebral cortex.

性能

应用

Our Abpromise guarantee covers the use of ab78395 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 57 kDa.
IHC-Fr Use a concentration of 1 - 2 µg/ml.

靶标

  • 功能Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5.
  • 组织特异性Expressed in all tissues tested including liver, muscle, testis, ovary, retinoblastoma cell line, neurons and brain (in which there was dense expression in substantia nigra, red nucleus, hippocampus and in cerebral cortical layers).
  • 序列相似性Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A1 subfamily.
  • 翻译后修饰Glycosylated.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • EAA3_HUMAN antibody
    • EAAC 1 antibody
    • EAAC1 antibody
    • EAAT 3 antibody
    • Excitatory amino acid carrier 1 antibody
    • Excitatory amino acid carrier1 antibody
    • Excitatory amino acid transporter 3 antibody
    • Excitatory amino acid transporter3 antibody
    • Excitatory amino-acid carrier 1 antibody
    • GLUTAMATE TRANSPORTER, HIGH-AFFINITY antibody
    • MEAAC 1 antibody
    • MEAAC1 antibody
    • Neuronal and epithelial glutamate transporter antibody
    • REAAC 1 antibody
    • REAAC1 antibody
    • Slc1 a1 antibody
    • Slc1a 1 antibody
    • SLC1A1 antibody
    • Sodium dependent glutamate/aspartate transporter 3 antibody
    • Sodium-dependent glutamate/aspartate transporter 3 antibody
    • Solute carrier family 1 (neuronal / epithelial high affinity glutamate transporter, system Xag), member 1 antibody
    • SOLUTE CARRIER FAMILY 1 (NEURONAL/EPITHELIAL HIGH AFFINITY GLUTAMATE TRANSPORTER), MEMBER 1 antibody
    • Solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 antibody
    • Solute carrier family 1 member 1 antibody
    • Solute carrier family 1, member 1 antibody
    see all

Anti-EAAT3 antibody [4D6.2] 图像

  • ab78395, at 1µg/ml, staining EAAT3 in rat cerebral cortex by Immunohistochemistry.

Anti-EAAT3 antibody [4D6.2] (ab78395)参考文献

This product has been referenced in:
  • Wei YB  et al. MicroRNA 101b Is Downregulated in the Prefrontal Cortex of a Genetic Model of Depression and Targets the Glutamate Transporter SLC1A1 (EAAT3) in Vitro. Int J Neuropsychopharmacol N/A:N/A (2016). Rat . Read more (PubMed: 27507301) »
  • Lane MC  et al. Genetic deletion of the neuronal glutamate transporter, EAAC1, results in decreased neuronal death after pilocarpine-induced status epilepticus. Neurochem Int N/A:N/A (2013). ICC/IF ; Mouse . Read more (PubMed: 24334055) »

See all 2 Publications for this product

Product Wall



Pour le ab78395 : la source de cet anticorps recommande le protocole Western Blot utilisé dans l'article deLevenson, J., et al., Nature Neuroscience (2002) 5:155-161.L'agent bloquant recommendé est le lait à5%;pour la dil...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"