Anti-E3 SUMO-protein ligase PIAS4抗体[PIA4] (ab61405)

概述

  • 产品名称Anti-E3 SUMO-protein ligase PIAS4抗体[PIA4]
    参阅全部 E3 SUMO-protein ligase PIAS4 一抗
  • 描述
    小鼠单克隆抗体[PIA4] to E3 SUMO-protein ligase PIAS4
  • 经测试应用适用于: WB, ICC, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rat, Cow
  • 免疫原

    Synthetic peptide:

    EEGPRPKRRC PFQK

    , corresponding to amino acids 491-504 of Human PAIAS gamma

  • 阳性对照
    • WB: total cell extract of HEK-293T cells transfected with human PAIAS gamma

性能

应用

Our Abpromise guarantee covers the use of ab61405 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 57 kDa.
ICC Use at an assay dependent dilution.
ELISA Use at an assay dependent dilution.

靶标

  • 功能Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Promotes PARK7 sumoylation. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations.
  • 组织特异性Highly expressed in testis and, at lower levels, in spleen, prostate, ovary, colon and peripheral blood leukocytes.
  • 通路Protein modification; protein sumoylation.
  • 序列相似性Belongs to the PIAS family.
    Contains 1 PINIT domain.
    Contains 1 SAP domain.
    Contains 1 SP-RING-type zinc finger.
  • 结构域The LXXLL motif is a coregulator signature that is essential for transcriptional corepression.
  • 翻译后修饰Sumoylated. Lys-35 is the main site of sumoylation. Sumoylation is required for TCF4 sumoylation and transcriptional activitation. Represses LEF1 transcriptional activity. SUMO1 is the preferred conjugate.
  • 细胞定位Nucleus > PML body. Colocalizes with SUMO1 and TCF7L2/TCF4 and LEF1 in a subset of PML (promyelocytic leukemia) nuclear bodies.
  • Information by UniProt
  • 数据库链接
  • 别名
    • E3 SUMO protein ligase PIAS4 antibody
    • E3 SUMO-protein ligase PIAS4 antibody
    • FLJ12419 antibody
    • MGC35296 antibody
    • PAIASgamma antibody
    • PIAS 4 antibody
    • PIAS gamma antibody
    • PIAS-gamma antibody
    • Pias4 antibody
    • PIAS4_HUMAN antibody
    • PIASG antibody
    • PIASgamma antibody
    • PIASy antibody
    • Protein inhibitor of activated STAT 4 antibody
    • Protein inhibitor of activated STAT protein 4 antibody
    • Protein inhibitor of activated STAT protein gamma antibody
    • Protein inhibitor of activated STAT protein PIASy antibody
    • Zinc finger MIZ type containing 6 antibody
    • ZMIZ 6 antibody
    • ZMIZ6 antibody
    see all

Anti-E3 SUMO-protein ligase PIAS4 antibody [PIA4] (ab61405)参考文献

ab61405 has not yet been referenced specifically in any publications.

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