概述

  • 产品名称
  • 描述
    山羊多克隆抗体to DYX1C1
  • 特异性
    ab81986 is expected to recognize three reported isoforms (NP_570722.2, NP_001028731.1 and NP_001028732.1).
  • 经测试应用
    适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Dog, Chimpanzee, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide:

    PLQVSDYSWQQTKT-C

    , corresponding to N terminal amino acids 2-15 of human DYX1C1 (NP_570722.2; NP_001028731.1; NP_001028732.1).

  • 阳性对照
    • Human brain (cerebral cortex and frontal cortex) lysates.

性能

应用

Our Abpromise guarantee covers the use of ab81986 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明
    Peptide ELISA: Antibody detection limit dilution 1/32000.
    WB: Use at a concentration of 0.5 - 1.5 µg/ml. Predicted molecular weight: 48 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能
      Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity.
    • 组织特异性
      Expressed in several tissues, including brain, lung, kidney and testis. In brain localizes to a fraction of cortical neurons and white matter glial cells.
    • 疾病相关
      Defects in DYX1C1 may be a cause of susceptibility to dyslexia type 1 (DYX1) [MIM:127700]. A relatively common, complex cognitive disorder characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities. It is a multifactorial trait, with evidence for familial clustering and heritability. Note=A chromosomal aberration involving DYX1C1 has been found in a family affected by dyslexia. Translocation t(2;15)(q11;q21).
    • 序列相似性
      Contains 1 CS domain.
      Contains 3 TPR repeats.
    • 细胞定位
      Nucleus. Cytoplasm.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Dyslexia susceptibility 1 candidate 1 antibody
      • Dyslexia susceptibility 1 candidate gene 1 protein antibody
      • DYX1 antibody
      • DYX1C1 antibody
      • DYXC1 antibody
      • DYXC1_HUMAN antibody
      • EKN1 antibody
      • FLJ37882 antibody
      • MGC70618 antibody
      • RD antibody
      see all

    Anti-DYX1C1 antibody 图像

    • Anti-DYX1C1 antibody (ab81986) at 0.5 µg/ml + human brain (frontal cortex) lysate (in RIPA buffer) at 35 µg
      Developed using the ECL technique

      Predicted band size : 48 kDa
      Observed band size : 48 kDa
      Additional bands at : 40 kDa. We are unsure as to the identity of these extra bands.

    实验方案

    Anti-DYX1C1 antibody (ab81986)参考文献

    ab81986 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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