Anti-Dystrophia myotonica protein kinase抗体(ab54731)

概述

  • 产品名称Anti-Dystrophia myotonica protein kinase抗体
    参阅全部 Dystrophia myotonica protein kinase 一抗
  • 描述
    小鼠单克隆抗体to Dystrophia myotonica protein kinase
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Recombinant Fragment
    预测可用于: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 303-421 of Human Dystrophia myotonica protein kinase

性能

应用

Our Abpromise guarantee covers the use of ab54731 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity. Phosphorylates phospholamban.
    • 组织特异性Most isoforms are expressed in many tissues including heart, skeletal muscle, liver and brain, except for isoform 2 which is only found in the heart and skeletal muscle, and isoform 14 which is only found in the brain, with high levels in the striatum, cerebellar cortex and pons.
    • 疾病相关Defects in DMPK are the cause of dystrophia myotonica type 1 (DM1) [MIM:160900]; also known as Steinert disease. A muscular disorder characterized by myotonia, muscle wasting in the distal extremities, cataract, hypogonadism, defective endocrine functions, male baldness and cardiac arrhythmias. Note=The causative mutation is a CTG expansion in the 3'-UTR of the DMPK gene. A length exceeding 50 CTG repeats is pathogenic, while normal individuals have 5 to 37 repeats. Intermediate alleles with 35-49 triplets are not disease-causing but show instability in intergenerational transmissions. Disease severity varies with the number of repeats: mildly affected persons have 50 to 150 repeats, patients with classic DM have 100 to 1,000 repeats, and those with congenital onset can have more than 2,000 repeats.
    • 序列相似性Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
      Contains 1 AGC-kinase C-terminal domain.
      Contains 1 protein kinase domain.
    • Information by UniProt
    • 数据库链接
    • 别名
      • DM 1 antibody
      • DM antibody
      • DM kinase antibody
      • DM protein kinase antibody
      • DM-kinase antibody
      • DM1 antibody
      • DM1 protein kinase antibody
      • DM1PK antibody
      • DMK antibody
      • DMPK antibody
      • DMPK_HUMAN antibody
      • Dystrophia myotonica 1 antibody
      • Dystrophia myotonica protein kinase antibody
      • MDPK antibody
      • MT PK antibody
      • MT-PK antibody
      • Myotonic dystrophy associated protein kinase antibody
      • Myotonic dystrophy protein kinase antibody
      • Myotonin protein kinase A antibody
      • Myotonin protein kinase antibody
      • Myotonin-protein kinase antibody
      • Thymopoietin homolog antibody
      see all

    Anti-Dystrophia myotonica protein kinase antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab54731 Dystrophia myotonica protein kinase antibody at 1ug/ml. Predicted band size of immunogen is 39 kDa.

      This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Anti-Dystrophia myotonica protein kinase antibody (ab54731)参考文献

    ab54731 has not yet been referenced specifically in any publications.

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