Anti-Dystrobrevin alpha抗体(ab72793)


  • 产品名称Anti-Dystrobrevin alpha抗体
    参阅全部 Dystrobrevin alpha 一抗
  • 描述
    小鼠多克隆抗体to Dystrobrevin alpha
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length Human Dystrobrevin alpha protein (Isoform 2, NP_116757.2).

  • 阳性对照
    • Dystrobrevin alpha transfected 293T cell lysate.



Our Abpromise guarantee covers the use of ab72793 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
  • 应用说明WB: 1/500 - 1/1000. Predicted molecular weight: Isoform 2, 75 kDa; Isoform 1, 84 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.
    • 组织特异性Highly expressed in brain, skeletal and cardiac muscles, and expressed at lower levels in lung, liver and pancreas. Isoform 2 is not expressed in cardiac muscle. Isoform 7 and isoform 8 are only expressed in muscle.
    • 疾病相关Defects in DTNA are the cause of left ventricular non-compaction type 1 (LVNC1) [MIM:604169]. Left ventricular non-compaction is due to an arrest of myocardial morphogenesis. The disorder is characterized by a hypertrophic left ventricule with deep trabeculations and with poor systolic function, with or without associated left ventricular dilation. In some cases, it is associated with other congenital heart anomalies such as ventricular septal defects, pulmonic stenosis and atrial septal defects. The right ventricle may also be affected.
    • 序列相似性Belongs to the dystrophin family. Dystrobrevin subfamily.
      Contains 1 ZZ-type zinc finger.
    • 结构域The coiled coil domain mediates the interaction with dystrophin and utrophin.
    • 翻译后修饰Phosphorylation of DTN-1 on tyrosine kinase substrate domain present in the C-terminus.
    • 细胞定位Cytoplasm. Cell junction > synapse. Cell membrane. In peripheral nerves, co-localizes with MAGEE1 in the Schwann cell membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Alpha-dystrobrevin antibody
      • D18S892E antibody
      • DRP3 antibody
      • DTN antibody
      • DTN-A antibody
      • DTNA antibody
      • DTNA_HUMAN antibody
      • Dystrobrevin alpha antibody
      • Dystrophin related protein 3 antibody
      • Dystrophin-related protein 3 antibody
      • FLJ96209 antibody
      • LVNC1 antibody
      • OTTHUMP00000163151 antibody
      • OTTHUMP00000163152 antibody
      • OTTHUMP00000163153 antibody
      • OTTHUMP00000163154 antibody
      • OTTHUMP00000163155 antibody
      see all

    Anti-Dystrobrevin alpha antibody 图像

    • All lanes : Anti-Dystrobrevin alpha antibody (ab72793) at 1/500 dilution

      Lane 1 : Dystrobrevin alpha transfected 293T cell lysate
      Lane 2 : Non transfected 293T cell lysate

      Lysates/proteins at 25 µg per lane.

      Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

      Predicted band size : 75 kDa
      Observed band size : 90 kDa (why is the actual band size different from the predicted?)

    Anti-Dystrobrevin alpha antibody (ab72793)参考文献

    ab72793 has not yet been referenced specifically in any publications.

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