Anti-Dystrobrevin alpha抗体(ab112949)

概述

  • 产品名称Anti-Dystrobrevin alpha抗体
    参阅全部 Dystrobrevin alpha 一抗
  • 描述
    兔多克隆抗体to Dystrobrevin alpha
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 691-721 of Human Dystrobrevin alpha (NP_001381.2, NP_116760.2, NP_116763.1, NP_001382.2, NP_001383.2, NP_116761.2, NP_116757.2 and NP_116762.2).

  • 阳性对照
    • Mouse heart tissue lysates

性能

应用

Our Abpromise guarantee covers the use of ab112949 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 84 kDa.

靶标

  • 功能May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors.
  • 组织特异性Highly expressed in brain, skeletal and cardiac muscles, and expressed at lower levels in lung, liver and pancreas. Isoform 2 is not expressed in cardiac muscle. Isoform 7 and isoform 8 are only expressed in muscle.
  • 疾病相关Defects in DTNA are the cause of left ventricular non-compaction type 1 (LVNC1) [MIM:604169]. Left ventricular non-compaction is due to an arrest of myocardial morphogenesis. The disorder is characterized by a hypertrophic left ventricule with deep trabeculations and with poor systolic function, with or without associated left ventricular dilation. In some cases, it is associated with other congenital heart anomalies such as ventricular septal defects, pulmonic stenosis and atrial septal defects. The right ventricle may also be affected.
  • 序列相似性Belongs to the dystrophin family. Dystrobrevin subfamily.
    Contains 1 ZZ-type zinc finger.
  • 结构域The coiled coil domain mediates the interaction with dystrophin and utrophin.
  • 翻译后修饰Phosphorylation of DTN-1 on tyrosine kinase substrate domain present in the C-terminus.
  • 细胞定位Cytoplasm. Cell junction > synapse. Cell membrane. In peripheral nerves, co-localizes with MAGEE1 in the Schwann cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Alpha-dystrobrevin antibody
    • D18S892E antibody
    • DRP3 antibody
    • DTN antibody
    • DTN-A antibody
    • DTNA antibody
    • DTNA_HUMAN antibody
    • Dystrobrevin alpha antibody
    • Dystrophin related protein 3 antibody
    • Dystrophin-related protein 3 antibody
    • FLJ96209 antibody
    • LVNC1 antibody
    • OTTHUMP00000163151 antibody
    • OTTHUMP00000163152 antibody
    • OTTHUMP00000163153 antibody
    • OTTHUMP00000163154 antibody
    • OTTHUMP00000163155 antibody
    see all

Anti-Dystrobrevin alpha antibody 图像

  • Anti-Dystrobrevin alpha antibody (ab112949) at 1/100 dilution + Mouse heart tissue lysates at 35 µg

    Predicted band size : 84 kDa

Anti-Dystrobrevin alpha antibody (ab112949)参考文献

ab112949 has not yet been referenced specifically in any publications.

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