概述

  • 产品名称Anti-Dystonin抗体
  • 描述
    小鼠单克隆抗体to Dystonin
  • 经测试应用适用于: Sandwich ELISA, ICC/IF, WB, IHC-Frmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Recombinant fragment: EDKLILAGNA LQSDSKRLES GVQFQNEAEI AGYILECENL LRQHVIDVQI LIDGKYYQAD QLVQRVAKLR DEIMALRNEC SSVYSKGRIL TTEQTKLMIS , corresponding to amino acids 401-501 of Human Dystonin

性能

应用

Our Abpromise guarantee covers the use of ab55654 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Sandwich ELISA Use at an assay dependent concentration.
ICC/IF Use a concentration of 10 µg/ml.
WB Use a concentration of 1 - 5 µg/ml.
IHC-Fr Use at an assay dependent concentration. PubMed: 18638474

靶标

  • 相关性Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Isoform 3: plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity. Isoform 6: required for bundling actin filaments around the nucleus By similarity. Isoform 7: regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport.
  • 细胞定位Cytoplasm › cytoskeleton.
  • 数据库链接
  • 别名
    • 230 kDa bullous pemphigoid antigen antibody
    • 230/240 kDa bullous pemphigoid antigen antibody
    • BP230 antibody
    • BP240 antibody
    • BPA antibody
    • BPAG1 antibody
    • Bullous pemphigoid antigen 1 antibody
    • Bullous pemphigoid antigen antibody
    • DMH antibody
    • DST antibody
    • DT antibody
    • Dystonia musculorum protein antibody
    • Hemidesmosomal plaque protein antibody
    • KIAA0728 antibody
    see all

Anti-Dystonin antibody 图像

  • Immunofluorescent staining of HeLa cells using ab55654 at 10 μg/mL.

  • Western blot against tagged recombinant protein immunogen using ab55654 Dystonin antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

Anti-Dystonin antibody (ab55654)参考文献

This product has been referenced in:
  • Young KG & Kothary R Dystonin/Bpag1 is a necessary endoplasmic reticulum/nuclear envelope protein in sensory neurons. Exp Cell Res 314:2750-61 (2008). IHC-Fr ; Mouse . Read more (PubMed: 18638474) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"