Anti-Dysbindin抗体[EPR7042(B)] (ab124967)


  • 产品名称Anti-Dysbindin抗体[EPR7042(B)]
    参阅全部 Dysbindin 一抗
  • 描述
    兔单克隆抗体[EPR7042(B)] to Dysbindin
  • 经测试应用适用于: WB, IP, Flow Cyt, ICC/IFmore details
    不适用于: IHC-P
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to residues at the C-terminus of Human Dysbindin (Q96EV8).

  • 阳性对照
    • SH-SY5Y, HeLa, HepG2, and 293T cell lysates
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.


  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 解离常数(KD KD = 2.34 x 10 -11 M Learn more about KD
  • 存储溶液pH: 7.40
    Preservative: 0.01% Sodium azide
    Constituents: 50% Glycerol, 0.05% BSA
  • 纯度Tissue culture supernatant
  • 克隆单克隆
  • 克隆编号EPR7042(B)
  • 同种型IgG
  • 研究领域


Our Abpromise guarantee covers the use of ab124967 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Predicted molecular weight: 39 kDa.
IP 1/10 - 1/100.
Flow Cyt 1/100 - 1/500.

ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.

ICC/IF 1/50 - 1/100.
  • 应用说明Is unsuitable for IHC-P.
  • 靶标

    • 功能The BLOC-1 complex is required for normal biogenesis of lysosome-related organelles, such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. May be required for normal dopamine homeostasis in the cerebral cortex, hippocampus, and hypothalamus. Plays a role in the regulation of cell surface exposure of DRD2. Contributes to the regulation of dopamine signaling. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation.
    • 组织特异性Detected in brain, in neurons and in neuropil. Detected in dentate gyrus and in pyramidal cells of hippocampus CA2 and CA3 (at protein level).
    • 疾病相关Defects in DTNBP1 are the cause of Hermansky-Pudlak syndrome type 7 (HPS7) [MIM:203300]. Hermansky-Pudlak syndrome (HPS) is a genetically heterogeneous, rare, autosomal recessive disorder characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects. This syndrome results from defects of diverse cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes. Ceroid storage in the lungs is associated with pulmonary fibrosis, a common cause of premature death in individuals with HPS.
    • 序列相似性Belongs to the dysbindin family.
    • 翻译后修饰Ubiquitinated by TRIM32. Ubiquitination leads to DTNBP1 degradation.
      Phosphorylated by PRKDC.
    • 细胞定位Cytoplasm. Cytoplasmic vesicle membrane. Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Endosome membrane. Melanosome membrane. Nucleus. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Endoplasmic reticulum. Detected in neuron cell bodies, axons and dendrites. Detected at synapses, at post-synaptic density, at pre-synaptic vesicle membranes and microtubules. Detected at tubulovesicular elements in the vicinity of the Golgi apparatus and of melanosomes. Occasionally detected at the membrane of pigmented melanosomes in cultured melanoma cells.
    • Information by UniProt
    • 数据库链接
    • 别名
      • DTBP1_HUMAN antibody
      • DTNBP1 antibody
      • Dysbindin antibody
      • Dysbindin-1 antibody
      • Dystrobrevin binding protein 1 antibody
      • Dystrobrevin-binding protein 1 antibody
      • Hermansky Pudlak syndrome 7 protein antibody
      • Hermansky-Pudlak syndrome 7 protein antibody
      • HPS7 antibody
      • HPS7 protein antibody
      see all

    Anti-Dysbindin antibody [EPR7042(B)] 图像

    • All lanes : Anti-Dysbindin antibody [EPR7042(B)] (ab124967) at 1/1000 dilution

      Lane 1 : SH-SY5Y cell lysate
      Lane 2 : HeLa cell lysate
      Lane 3 : HepG2 cell lysate
      Lane 4 : 293T cell lysate

      Lysates/proteins at 10 µg per lane.

      HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 39 kDa
    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    Anti-Dysbindin antibody [EPR7042(B)] (ab124967)参考文献

    ab124967 has not yet been referenced specifically in any publications.

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