概述

  • 产品名称Anti-DYRK2抗体
    参阅全部 DYRK2 一抗
  • 描述
    小鼠单克隆抗体to DYRK2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: MNDHLHVGSH AHGQIQVQQL FEDNSNKRTV LTTQPNGLTT VGKTGLPVVP ERQLDSIHRR QGSSTSLKSM EGMGKVKATP MTPEQAMKQY MQKLTAFEHH , corresponding to amino acids 1-100 of Human DYRK2

性能

应用

Our Abpromise guarantee covers the use of ab56363 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Role in the regulation of cellular growth and/or development. Regulates TP53 by phosphorylation on Ser-46 to induce apoptosis in response to DNA damage, functioning downstream of ATM. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates.
    • 组织特异性Testis, after the onset of spermatogenesis.
    • 序列相似性Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
      Contains 1 protein kinase domain.
    • 翻译后修饰Phosphorylated on serine/threonine residues.
    • 细胞定位Cytoplasm. Nucleus. Translocates into the nucleus following DNA damage.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 1810038L18Rik antibody
      • Dual specificity tyrosine (Y) phosphorylation regulated kinase 2 antibody
      • Dual specificity tyrosine phosphorylation regulated kinase 2 antibody
      • Dual specificity tyrosine-phosphorylation-regulated kinase 2 antibody
      • DYRK2 antibody
      • DYRK2_HUMAN antibody
      • EC 2.7.12.1 antibody
      • FLJ21217 antibody
      • FLJ21365 antibody
      see all

    Anti-DYRK2 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab56363 DYRK2 antibody at 1ug/ml. Predicted band size of immunogen is 34 kDa
    • Western Blot analysis of DYRK2 expression in transfected 293T cell line by ab56363.

      Lane 1: DYRK2 transfected lysate(59.7 KDa).
      Lane 2: Non-transfected lysate.

    Anti-DYRK2 antibody (ab56363)参考文献

    ab56363 has not yet been referenced specifically in any publications.

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