概述

  • 产品名称Anti-Dyrk1B抗体
    参阅全部 Dyrk1B 一抗
  • 描述
    小鼠多克隆抗体to Dyrk1B
  • 特异性This antibody is reactive against mammalian transfected lysate.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Dyrk1B (NP_004705.1, 1 a.a. ~ 629 a.a) full-length human protein.

  • 阳性对照
    • Transfected 293T cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab69879 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 75 kDa (predicted molecular weight: 69 kDa).

靶标

  • 功能Dual-specificity kinase which possesses both serine/ threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments.
  • 组织特异性Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines.
  • 序列相似性Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.
    Contains 1 protein kinase domain.
  • 翻译后修饰Autophosphorylated on tyrosine residues. Phosphorylated by MAP kinase. Tyrosine phosphorylation may be required for dimerization.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AOMS3 antibody
    • Dual specificity tyrosine (Y) phosphorylation regulated kinase 1B antibody
    • Dual specificity tyrosine phosphorylation regulated kinase 1B antibody
    • Dual specificity tyrosine-phosphorylation-regulated kinase 1B antibody
    • DYR 1B antibody
    • DYR1A antibody
    • DYR1B antibody
    • DYR1B_HUMAN antibody
    • DYRK 1B antibody
    • Dyrk1b antibody
    • Minibrain related kinase antibody
    • Minibrain-related kinase antibody
    • MIRK antibody
    • Mirk protein kinase antibody
    see all

Anti-Dyrk1B antibody 图像

  • All lanes : Anti-Dyrk1B antibody (ab69879) at 1/500 dilution

    Lane 1 : Dyrk1B transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 69 kDa
    Observed band size : 75 kDa (why is the actual band size different from the predicted?)

Anti-Dyrk1B antibody (ab69879)参考文献

ab69879 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab69879.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"