Anti-Dynorphin B抗体(Biotin) (ab48239)

概述

  • 产品名称Anti-Dynorphin B抗体(Biotin)
    参阅全部 Dynorphin B 一抗
  • 描述
    兔多克隆抗体to Dynorphin B (Biotin)
  • 偶联物Biotin
  • 特异性This antibody is specific for Dynorphin B.
  • 经测试应用适用于: RIA, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Guinea pig, Cow, Pig
  • 免疫原

    Synthetic peptide:

    CYGGFLRRQF

    conjugated to KLH via Cysteine, corresponding to amino acids 226-234 of Human Dynorphin B

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 50% Glycerol, PBS, pH 7.5
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab48239 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
RIA Use at an assay dependent dilution.
ELISA Use at an assay dependent dilution.

靶标

  • 功能Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
    Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.
    Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
  • 疾病相关Defects in PDYN are the cause of spinocerebellar ataxia type 23 (SCA23) [MIM:610245]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA23 is an adult-onset autosomal dominant form characterized by slowly progressive gait and limb ataxia, with variable additional features, including peripheral neuropathy and dysarthria.
  • 序列相似性Belongs to the opioid neuropeptide precursor family.
  • 翻译后修饰The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Beta-neoendorphin-dynorphin antibody
    • Big Dyn antibody
    • Dyn B antibody
    • Dyn-A17 antibody
    • Dyn-B antibody
    • Dynorphin A antibody
    • Dynorphin B antibody
    • Dynorphin B(1-13) antibody
    • Dynorphin B-29 antibody
    • Leumorphin antibody
    • PDYN antibody
    • PDYN_HUMAN antibody
    • Preprodynorphin antibody
    see all

Anti-Dynorphin B antibody (Biotin) (ab48239)参考文献

ab48239 has not yet been referenced specifically in any publications.

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