概述

  • 产品名称Anti-Dynorphin B抗体
    参阅全部 Dynorphin B 一抗
  • 描述
    兔多克隆抗体to Dynorphin B
  • 特异性This antibody blocks specifically with Dynorphin B 1-13. Cells are found in the paraventricular hypothalamic and the supraoptic nucleus in rat brain of colchicine treated 4% FA perfused tissue. Fibers are found in the lateral hypothalamus of both colchicine and normal rat brain of 4% FA perfused tissue.
  • 经测试应用适用于: IHC-FoFr, IHC-Fr, RIAmore details
  • 种属反应性
    与反应: Rat, Guinea pig, Hamster, Pig, Rhesus monkey
    预测可用于: Mouse, Cow, Human, Xenopus laevis
  • 免疫原

    Synthetic peptide:

    YGGFLRRQFKVVT

    , corresponding to amino acids 1-13 of Pig Dynorphin B. (Prodynorphin 228-240).

  • 常规说明This product should be stored undiluted. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: 1% BSA, Whole Serum, PBS
  • 纯度Whole antiserum
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab11135 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-FoFr Use at an assay dependent concentration. PubMed: 20206610
IHC-Fr 1/250 - 1/2500.
RIA 1/5000.

靶标

  • 功能Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
    Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.
    Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
  • 疾病相关Defects in PDYN are the cause of spinocerebellar ataxia type 23 (SCA23) [MIM:610245]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA23 is an adult-onset autosomal dominant form characterized by slowly progressive gait and limb ataxia, with variable additional features, including peripheral neuropathy and dysarthria.
  • 序列相似性Belongs to the opioid neuropeptide precursor family.
  • 翻译后修饰The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Beta-neoendorphin-dynorphin antibody
    • Big Dyn antibody
    • Dyn B antibody
    • Dyn-A17 antibody
    • Dyn-B antibody
    • Dynorphin A antibody
    • Dynorphin B antibody
    • Dynorphin B(1-13) antibody
    • Dynorphin B-29 antibody
    • Leumorphin antibody
    • PDYN antibody
    • PDYN_HUMAN antibody
    • Preprodynorphin antibody
    see all

Anti-Dynorphin B antibody (ab11135)参考文献

This product has been referenced in:
  • Amrein I & Slomianka L A morphologically distinct granule cell type in the dentate gyrus of the red fox correlates with adult hippocampal neurogenesis. Brain Res 1328:12-24 (2010). IHC-FoFr . Read more (PubMed: 20206610) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"