Anti-Dynorphin A抗体(ab40647)


  • 产品名称Anti-Dynorphin A抗体
    参阅全部 Dynorphin A 一抗
  • 描述
    兔多克隆抗体to Dynorphin A
  • 特异性This antibody shows specificity of: Dynorphin A (1-13) 100%; [Leu5]-Enkephalin 0%; [Met5]-Enkephalin 0% and b-Endorphin (human) 0%.
  • 经测试应用适用于: IHC-P, ELISA, RIA, ICCmore details
  • 种属反应性
    与反应: Human, Pig
    预测可用于: Mouse, Rat, Guinea pig, Cow, Chimpanzee, Zebrafish, Baboon, Cynomolgus Monkey, Macaque Monkey, Rhesus monkey, Gorilla
  • 免疫原

    Synthetic peptide:


    , corresponding to amino acids 1-13 of Dynorphin A


  • 形式Liquid
  • 存放说明Store at +4°C short term (1-2 weeks) (add antibacterial agent). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: Whole serum
  • 纯度Whole antiserum
  • 克隆多克隆
  • 同种型IgG
  • 研究领域


Our Abpromise guarantee covers the use of ab40647 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use at an assay dependent concentration. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ELISA Use at an assay dependent concentration. Cell culture filtrate or whole cells directly coated onto microtitre wells can be used.
RIA Use at an assay dependent concentration.
With this antibody, we have found that blocking with 5% goat or donkey serum significantly reduces background as compared to BSA or milk.
ICC Use at an assay dependent concentration.


  • 相关性Dynorphins are a class of peptides produced by many different populations of neurons, which has some opiate like activity. It is thus classed as an endogenous opioid peptide. The dynorphins, which include dynorphin A, dynorphin B, alpha and beta neoendorphin, and big dynorphin, are all the products of a single gene, 'preprodynorphin'. Dynorphin is produced in many different parts of the brain, including the hypothalamus, the hippocampus and the spinal cord, and has many different physiological actions, depending upon its site of production. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. As such, it may help some individuals against addiction. Blocking dynorphin may help alleviate depression.
  • 细胞定位Secreted
  • 数据库链接
  • 别名
    • Beta neoendorphin dynorphin antibody
    • Dyn A17 antibody
    • Dynorphin A antibody
    • PDYN antibody
    • Preprodynorphin antibody
    • Proenkephalin B antibody
    see all

Anti-Dynorphin A antibody 图像

  • IHC image of ab40647 staining in human hippocampus formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab40647, 1/1000 dilution, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

    For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-Dynorphin A antibody (ab40647)参考文献

ab40647 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your call yesterday and for your question about these antibodies. I apologize for the delay getting back to you.

We have a general IHC protocol for FFPE sections that includes a section on antigen retrieval-


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