概述

  • 产品名称Anti-Dynorphin A抗体
    参阅全部 Dynorphin A 一抗
  • 描述
    兔多克隆抗体to Dynorphin A
  • 特异性This antibody blocks with dynorphin 1-17 and 1-8 but not with other related peptides. Cells are found in the paraventricular and supraoptic nucleus and fibers are found in the lateral hypothalamus in rat brain of 4% FA perfused colchicine tissue.
  • 经测试应用适用于: IHC-Fr, IHC-P, RIAmore details
  • 种属反应性
    与反应: Mouse, Rat, Human, Pig, Rhesus monkey
    预测可用于: Guinea pig, Cow
  • 免疫原

    Synthetic peptide:

    YGGFLRRIRPKLKWDNQ

    (Pig).

  • 常规说明This product should be stored undiluted. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Whole Serum, PBS
  • 纯度Whole antiserum
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab11134 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr 1/100 - 1/1500.
IHC-P Use at an assay dependent concentration. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
RIA 1/10000.

靶标

  • 相关性Dynorphins are a class of peptides produced by many different populations of neurons, which has some opiate like activity. It is thus classed as an endogenous opioid peptide. The dynorphins, which include dynorphin A, dynorphin B, alpha and beta neoendorphin, and big dynorphin, are all the products of a single gene, 'preprodynorphin'. Dynorphin is produced in many different parts of the brain, including the hypothalamus, the hippocampus and the spinal cord, and has many different physiological actions, depending upon its site of production. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. As such, it may help some individuals against addiction. Blocking dynorphin may help alleviate depression.
  • 细胞定位Secreted
  • 数据库链接
  • 别名
    • Beta neoendorphin dynorphin antibody
    • Dyn A17 antibody
    • Dynorphin A antibody
    • PDYN antibody
    • Preprodynorphin antibody
    • Proenkephalin B antibody
    see all

Anti-Dynorphin A antibody (ab11134)参考文献

This product has been referenced in:
  • Olsen J  et al. Intimate associations between the endogenous opiate systems and the growth hormone-releasing hormone system in the human hypothalamus. Neuroscience 258:238-45 (2014). Read more (PubMed: 24239719) »
  • Labuz D  et al. Immune cell-derived opioids protect against neuropathic pain in mice. J Clin Invest 119:278-86 (2009). IHC-Fr ; Mouse . Read more (PubMed: 19139563) »

See all 3 Publications for this product

Product Wall

Thank you for your call yesterday and for your question about these antibodies. I apologize for the delay getting back to you.

We have a general IHC protocol for FFPE sections that includes a section on antigen retrieval-

http://www...

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1. The serum is diluted in PBS, unfortunately we do not have the exact amount that is diluted, however we can estimate the specific antibody concentration to be 0.5-1.0mg/ml. 2. Unfortunately, I have been unsuccessful in locating information to su...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"