概述

  • 产品名称Anti-DYNLT3抗体
  • 描述
    兔多克隆抗体to DYNLT3
  • 经测试应用适用于: IHC-P, WB, ICC/IFmore details
  • 种属反应性
    与反应: Rat, Human
  • 免疫原

    antigen sequence: DEVGFNAEEA HNIVKECVDG VLGGEDYNHN NINQWTASIV EQSLTHLVKL GKAYKYIVTC AVVQKSAYGF HTASSCFWDT TSDGTCTVRW E, corresponding to amino acids 9-99 of Human DYNLT3.

  • 阳性对照
    • U 251 MG cells; RT 4, U 251 MG, Human liver and Human tonsil lysates; Human cerebral cortex tissue.

性能

应用

Our Abpromise guarantee covers the use of ab121209 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/1000 - 1/2500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/100 - 1/250.
ICC/IF Use a concentration of 1 - 4 µg/ml. Fixation/Permeabilization: PFA/Triton X-100.

靶标

  • 功能Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis.
  • 序列相似性Belongs to the dynein light chain Tctex-type family.
  • 细胞定位Nucleus. Cytoplasm > cytoskeleton. Chromosome > centromere > kinetochore. Colocalizes with BUB3 at kinetochores specifically during prometaphase.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 2310075M16Rik antibody
    • AU042796 antibody
    • DYLT3_HUMAN antibody
    • Dynein light chain Tctex-type 3 antibody
    • DYNLT3 antibody
    • Protein 91/23 antibody
    • RP23-256J17.2 antibody
    • RP3 antibody
    • T-complex-associated testis-expressed 1-like antibody
    • Tcte1l antibody
    • TCTEX1L antibody
    see all

Anti-DYNLT3 antibody 图像

  • ab121209 at 1/750 dilution staining DYNLT3 in Paraffin-embedded Human cerebral cortex tissue by Immunohistochemistry.
  • All lanes : Anti-DYNLT3 antibody (ab121209) at 1/250 dilution

    Lane 1 : RT 4 lysate
    Lane 2 : U 251 MG lysate
    Lane 3 : Human plasma lysate
    Lane 4 : Human liver lysate
    Lane 5 : Human tonsil lysate
  • ab121209 at 4 µg/ml staining DYNLT3 in PFA/Triton X-100 fixed/permeabilized U 251 MG cells by Immunofluorescence (green).

Anti-DYNLT3 antibody (ab121209)参考文献

This product has been referenced in:
  • Chu Y  et al. Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease. Brain 135:2058-73 (2012). ICC/IF ; Rat . Read more (PubMed: 22719003) »

See 1 Publication for this product

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